ArticleAmerican journal of obstetrics and gynecology2008
Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression.
Article in American journal of obstetrics and gynecology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Association between early exposure to famine and risk of renal impairment in adulthood: a systematic review and meta-analysis.Nutrition & diabetes · 2024Pooled it
- Impact of diet and exercise in growth restricted female rats on nephron endowment in male fetuses.Experimental physiology · 2026Article
- Maternal Diet High in Linoleic Acid Alters Renal Branching Morphogenesis and mTOR/AKT Signalling Genes in Rat Fetal Kidneys.International journal of molecular sciences · 2024Article
- Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney.Journal of the American Society of Nephrology : JASN · 2021Article
- Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects.Cell death & disease · 2020Article
- Shaping of the nephron - a complex, vulnerable, and poorly explored backdrop for noxae impairing nephrogenesis in the fetal human kidney.Molecular and cellular pediatrics · 2020Article
- Perfusion culture maintained with an air-liquid interface to stimulate epithelial cell organization in renal organoids in vitro.BMC biomedical engineering · 2019Article
- The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models.Journal of translational medicine · 2016Article
- Changes in renal WT-1 expression preceding hypertension development.BMC nephrology · 2016Article
- Understanding the role of maternal diet on kidney development; an opportunity to improve cardiovascular and renal health for future generations.Nutrients · 2015Review
- Melatonin therapy prevents programmed hypertension and nitric oxide deficiency in offspring exposed to maternal caloric restriction.Oxidative medicine and cellular longevity · 2014Article
- The impact of maternal cigarette smoke exposure in a rodent model on renal development in the offspring.PloS one · 2014Article
- PAX2 Expression in Ovarian Cancer.International journal of molecular sciences · 2013Article
- Developmental origins of chronic renal disease: an integrative hypothesis.International journal of nephrology · 2013Review
- microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells.PloS one · 2012Article
- Mechanisms of fetal programming in hypertension.International journal of pediatrics · 2012Article
- Early onset of fatty liver in growth-restricted rat fetuses and newborns.Congenital anomalies · 2011Article
- Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats.Pediatric nephrology (Berlin, Germany) · 2011Article
- Renal function, renal volume, and blood pressure in infants with antecedent of antenatal steroids.Pediatric nephrology (Berlin, Germany) · 2011Article
- Maternal undernourished fetal kidneys exhibit differential regulation of nephrogenic genes including downregulation of the Notch signaling pathway.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveMaternal food restriction during pregnancy results in growth-restricted newborns and reduced glomerular number, contributing to programmed offspring hypertension. We investigated whether reduced nephrogenesis may be programmed by dysregulation of factors controlling ureteric bud branching and mesenchyme to epithelial transformation. STUDY
designAt 10 to 20 days' gestation, Sprague Dawley pregnant rats (n = 6/group) received ad libitum food; food-restricted rats were 50% food restricted. At embryonic day 20, messenger ribonucleic acid (mRNA) and protein expression of Wilms' tumor 1 gene product (WT1), paired box transcription factor (Pax)-2, fibroblast growth factor (FGF)-2, glial cell line-derived neurotrophic factor (GDNF), cRET, wingless-type mouse mammary tumor virus integration site (WNT)4, WNT11, bone morphogenetic protein (BMP)-4, BMP7, and FGF7 were determined by real-time polymerase chain reaction and Western blotting.
resultsMaternal food restriction resulted in up-regulated mRNA expression for WT1, FGF2, and BMP7, whereas Pax2, GDNF, FGF7, BMP4, WNT4, and WNT11 mRNAs were down-regulated. Protein expression was concordant for WT1, GDNF, Pax2, FGF7, BMP4, and WNT4.
conclusionMaternal food restriction altered gene expression of fetal renal transcription and growth factors and likely contributes to development of offspring hypertension.
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