ReviewRespiratory physiology & neurobiology2008
Cell wounding and repair in ventilator injured lungs.
Review in Respiratory physiology & neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways.Respiratory research · 2023Article
- Article
- MircroRNA Let-7a-5p in Airway Smooth Muscle Cells is Most Responsive to High Stretch in Association With Cell Mechanics Modulation.Frontiers in physiology · 2022Article
- Implications of microscale lung damage for COVID-19 pulmonary ventilation dynamics: A narrative review.Life sciences · 2021Review
- Alveolar dynamics during mechanical ventilation in the healthy and injured lung.Intensive care medicine experimental · 2019Review
- The micromechanics of lung alveoli: structure and function of surfactant and tissue components.Histochemistry and cell biology · 2018Review
- Lung anatomy, energy load, and ventilator-induced lung injury.Intensive care medicine experimental · 2015Article
- Does high-pressure, high-frequency oscillation shake the foundations of lung protection?Intensive care medicine · 2015Article
- Computational analysis of microbubble flows in bifurcating airways: role of gravity, inertia, and surface tension.Journal of biomechanical engineering · 2014Article
- TRIM72 is required for effective repair of alveolar epithelial cell wounding.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Treatment of acute lung injury by targeting MG53-mediated cell membrane repair.Nature communications · 2014Article
- Effect of local tidal lung strain on inflammation in normal and lipopolysaccharide-exposed sheep*.Critical care medicine · 2014Article
- Strategies for whole lung tissue engineering.IEEE transactions on bio-medical engineering · 2014Article
- Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase.The FEBS journal · 2014Article
- [Lung protective ventilation in ARDS].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2013Review
- Visual anatomical lung CT scan assessment of lung recruitability.Intensive care medicine · 2013Article
- Atelectrauma disrupts pulmonary epithelial barrier integrity and alters the distribution of tight junction proteins ZO-1 and claudin 4.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Acid contact in the rodent pulmonary alveolus causes proinflammatory signaling by membrane pore formation.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition.Critical care medicine · 2012Article
- Mechanobiology in lung epithelial cells: measurements, perturbations, and responses.Comprehensive Physiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Acute lung injury (ALI) is a common, frequently hospital-acquired condition with a high morbidity and mortality. The stress associated with invasive mechanical ventilation represents a potentially harmful exposure, and attempts to minimize deforming stress through low tidal ventilation have proven efficacious. Lung cells are both sensors and transducers of deforming stress, and are frequently wounded in the setting of mechanical ventilation. Cell wounding may be one of the drivers of the innate immunologic and systemic inflammatory response associated with mechanical ventilation. These downstream effects of mechanotransduction have been referred to collectively as "Biotrauma". Our review will focus on cellular stress failure, that is cell wounding, and the mechanisms mediating subsequent plasma membrane repair, we hold that a better mechanistic understanding of cell plasticity, deformation associated remodeling and repair will reveal candidate approaches for lung protective interventions in mechanically ventilated patients. We will detail one such intervention, lung conditioning with hypertonic solutions as an example of ongoing research in this arena.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.