ReviewJournal of anatomy2008
Small intestinal stem cell markers.
Review in Journal of anatomy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- Discovery of the radio-protecting effect of Ecliptae Herba, its constituents and targeting p53-mediated apoptosisActa pharmaceutica Sinica. B · 2023Article
- Establishment of intestinal organoids from small intestine of growing cattle (12 months old).Journal of animal science and technology · 2022Article
- Reactive Oxygen Species in Modulating Intestinal Stem Cell Dynamics and Function.Stem cell reviews and reports · 2022Review
- Expression of SARS-CoV-2 entry factors, electrolyte, and mineral transporters in different mouse intestinal epithelial cell types.Physiological reports · 2021Article
- The Effects of Fecal Microbiota Transplantation on the Symptoms and the Duodenal Neurogenin 3, Musashi 1, and Enteroendocrine Cells in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.Frontiers in cellular and infection microbiology · 2021Article
- Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome.Molecular medicine reports · 2020Article
- Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome.World journal of gastroenterology · 2020Review
- Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice.RNA (New York, N.Y.) · 2020Article
- Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer.Colorectal cancer · 2019Article
- Diet in Irritable Bowel Syndrome (IBS): Interaction with Gut Microbiota and Gut Hormones.Nutrients · 2019Review
- Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types.BMC biology · 2018Article
- Increased Musashi-2 and Decreased NUMB Protein Levels Observed in Human Colorectal Cancer are reverted to Normal Levels by ATRA-Induced Cell Differentiation.International journal of cancer research & therapy · 2018Article
- Dclk1-expressing tuft cells: critical modulators of the intestinal niche?American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Abnormalities in ileal stem, neurogenin 3, and enteroendocrine cells in patients with irritable bowel syndrome.BMC gastroenterology · 2017Article
- Gastrointestinal neuroendocrine peptides/amines in inflammatory bowel disease.World journal of gastroenterology · 2017Review
- Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis.Molecular medicine reports · 2017Article
- Abnormalities in endocrine and immune cells are correlated in dextran‑sulfate‑sodium‑induced colitis in rats.Molecular medicine reports · 2017Article
- Preventive Effects of a Chinese Herbal Formula, Shengjiang Xiexin Decoction, on Irinotecan-Induced Delayed-Onset Diarrhea in Rats.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis.International journal of molecular medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Stem cells hold great promise for regenerative medicine but remain elusive in many tissues, including the small intestine, where it is well accepted that the epithelium is maintained by intestinal stem cells located in the crypts. The lack of established markers to prospectively identify intestinal stem cells has necessitated the use of indirect analysis, e.g. long-term label retention, which is based on the hypothesis that intestinal stem cells are slow-cycling. Several intestinal stem cell markers have been proposed, including Musashi-1, BMPR1alpha, phospho-PTEN, DCAMKL1, Eph receptors and integrins, but their validity, using functional and/or lineage tracing assays, has yet to be confirmed. Recently, Lgr5 has been identified by lineage tracing as an intestinal stem cell marker. In this review we summarize what is known about the currently reported intestinal stem cell markers and provide a rationale for developing model systems whereby intestinal stem cells can be functionally validated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.