ArticleBritish journal of clinical pharmacology2008
Case ascertainment and estimated incidence of drug-induced long-QT syndrome: study in Southwest France.
Article in British journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Risk of sudden unexplained death after use of dihydroartemisinin-piperaquine for malaria: a systematic review and Bayesian meta-analysis.The Lancet. Infectious diseases · 2018Pooled it
- Algorithms used to identify ventricular arrhythmias and sudden cardiac death in retrospective studies: a systematic literature review.Therapeutic advances in cardiovascular disease · 2018Pooled it
- ICD-10 codes used to identify adverse drug events in administrative data: a systematic review.Journal of the American Medical Informatics Association : JAMIAPooled it
- Drug-Induced QT Prolongation: Associations Between Risk Classifications in a Swedish Clinical Decision Support System and Clinical Outcomes.Clinical pharmacology and therapeutics · 2026Article
- Macrolide Antibiotic Mediated Cardiac Arrhythmias: Emerging Concepts and Clinical Implications.Biomedicines · 2025Review
- Overdrive Pacing for Persistent Torsades de Pointes and Pulseless Ventricular Tachycardia.Journal of acute medicine · 2024Article
- Spotlight on the 2022 ESC guideline management of ventricular arrhythmias and prevention of sudden cardiac death: 10 novel key aspects.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Review
- Prevalence and risk factors for acquired long QT syndrome in the emergency department: a retrospective observational study.World journal of emergency medicine · 2023Article
- Documentation of Drug-Related Problems with ICD-11: Application of the New WHO Code-Set to Clinical Routine Data.Journal of clinical medicine · 2022Article
- Emergency department admissions induced by drug-drug interactions in the elderly: A cross-sectional study.Clinical and translational science · 2022Article
- Vomiting, electrolyte disturbance, and medications; the perfect storm for acquired long QT syndrome and cardiac arrest: a case report.Journal of medical case reports · 2022Article
- Drug-induced torsades de pointes: Disproportionality analysis of the United States Food and Drug Administration adverse event reporting system.Frontiers in cardiovascular medicine · 2022Article
- Obesity Potentiates the Risk of Drug-Induced Long QT Syndrome - Preliminary Evidence from WNIN/Ob Spontaneously Obese Rat.Cardiovascular toxicology · 2021Article
- Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation.International journal of molecular sciences · 2021Review
- [Proarrhythmic adverse effects of nonarrhythmic drugs].Herzschrittmachertherapie & Elektrophysiologie · 2019Review
- Summary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative Chlorobutanol.Drug safety · 2019Article
- Acquired Long QT Syndrome and Electrophysiology of Torsade de Pointes.Arrhythmia & electrophysiology review · 2019Review
- Drug-Induced Arrhythmia: Bridging the Gap Between Pathophysiological Knowledge and Clinical Practice.Drug safety · 2017Article
- Targeted Cancer Therapies and QT Interval Prolongation: Unveiling the Mechanisms Underlying Arrhythmic Complications and the Need for Risk Stratification Strategies.Clinical drug investigation · 2017Review
- Life-threatening cardiac arrhythmias due to drug-induced QT prolongation : A retrospective study over 6 years from a medical intensive care unit.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this study was to investigate the incidence and reporting rate of drug-induced long-QT syndrome (LQTS) in France [defined by evidence of torsades de pointes (TdP), QT prolongation and exposure to a relevant drug] and to assess feasibility of case collection for drug-induced LQTS.
methodsA retrospective population-based study was carried out in Southwest France in five institutions: three main hospitals, one private clinic and one cardiac emergency unit, searched from 1 January 1999 to 1 January 2005 (population coverage of 614 000). The study population consisted of 861 cases with International Classification of Diseases-10 diagnostic codes for ventricular tachycardia (I147.2), ventricular fibrillation (I149.0) and sudden cardiac death (I146.1) from hospital discharge summaries, supplemented by cases reported to national or regional pharmacovigilance systems, and voluntary reporting by physicians, validated according to internationally defined criteria for drug-induced LQTS.
resultsOf 861 patients coded with arrhythmias or sudden cardiac death, there were 40 confirmed surviving acquired cases of drug-induced LQTS. We estimated that the incidence of those who survive to reach hospital drug-induced LQTS is approximately 10.9 per million annually in France (95% confidence interval 7.8, 14.8).
conclusionsMany cases of drug-induced LQTS may not survive before they reach hospital, as the reporting rate for drug-induced LQTS identified through the cardiology records and also reported to pharmacovigilance systems for the Midi-Pyrenees area is 3/40 (7.5%). Using the methods outlined it is possible to assemble cases to study genetic susceptibility to drug-induced LQTS and adapt these methods more widely.
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