ReviewBritish journal of clinical pharmacology2008
Post-mortem clinical pharmacology.
Review in British journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.
- Complete republication: National Association of Medical Examiners position paper: Recommendations for the investigation, diagnosis, and certification of deaths related to opioid drugs.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2014Guideline
- Runaway uncoupling in 2,4-dinitrophenol poisoning: Clinical and mitochondrial observations from two cases.Toxicology reports · 2026Article
- Postmortem Redistribution of Drugs Commonly Used in Rapid Sequence Induction for Anesthesia: A Review.Journal of clinical medicine · 2026Review
- Decomposition and medicolegal autopsy in geriatric in‑home non‑traumatic deaths: histopathological findings and a public health perspective.BMC geriatrics · 2026Article
- Difficulties associated with the interpretation of postmortem toxicology.Journal of analytical toxicology · 2024Article
- Fourteen Deaths from Suspected Heparin Overdose in an Italian Primary-Level Hospital.Diagnostics (Basel, Switzerland) · 2023Article
- A model of evaluative opinion to encourage greater transparency and justification of interpretation in postmortem forensic toxicology.Journal of analytical toxicology · 2023Article
- Postmortem concentrations of ropivacaine, bupivacaine, and lidocaine in femoral venous blood after hip fracture surgery.International journal of legal medicine · 2023Article
- Review
- On the driver of blood circulation beyond the heart.PloS one · 2023Article
- Case report on postmortem fentanyl measurement after overdose with more than 67 fentanyl patches.Forensic toxicology · 2022Article
- Article
- Back to the Future - Part 2. Post-mortem assessment and evolutionary role of the bio-medicolegal sciences.International journal of legal medicine · 2017Review
- Unintentional drowning: Role of medicinal drugs and alcohol.BMC public health · 2017Article
- Tracking pan-continental trends in environmental contamination using sentinel raptors-what types of samples should we use?Ecotoxicology (London, England) · 2016Article
- Dystrophic mineralization of the arterial fibrovascular tissue associated with a vitamin D hypervitaminosis in an 8-year-old female Alpaca (Irish veterinary journal · 2016Article
- Analytical data supporting the "theoretical" postmortem redistribution factor (Forensic sciences research · 2016Article
- The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- In silico ordinary differential equation/partial differential equation hemodialysis model estimates methadone removal during dialysis.Journal of pain research · 2015Article
- Drug concentrations in post-mortem femoral blood compared with therapeutic concentrations in plasma.Drug testing and analysis · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical pharmacology assumes that deductions can be made about the concentrations of drugs from a knowledge of the pharmacokinetic parameters in an individual; and that the effects are related to the measured concentration. Post-mortem changes render the assumptions of clinical pharmacology largely invalid, and make the interpretation of concentrations measured in post-mortem samples difficult or impossible. Qualitative tests can show the presence of substances that were not present in life, and can fail to detect substances that led to death. Quantitative analysis is subject to error in itself, and because post-mortem concentrations vary in largely unpredictable ways with the site and time of sampling, as a result of the phenomenon of post-mortem redistribution. Consequently, compilations of 'lethal concentrations' are misleading. There is a lack of adequate studies of the true relationship between fatal events and the concentrations that can be measured subsequently, but without such studies, clinical pharmacologists and others should be wary of interpreting post-mortem measurements.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.