ArticleBMC cardiovascular disorders2008
RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population.
Article in BMC cardiovascular disorders, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Potential Gene Association Studies of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- The association of maternal ACE A11860G with small for gestational age babies is modulated by the environment and by fetal sex: a multicentre prospective case-control study.Molecular human reproduction · 2013Trial
- Severe left main coronary artery disease and STEMI in a 19-year-old without traditional risk factors: A rare case of premature coronary artery disease.SAGE open medical case reports · 2025Article
- Polymorphism Patterns and Socioeconomic Characteristics and Their Influence on the Risk of Preeclampsia.Medicina (Kaunas, Lithuania) · 2024Article
- Tetra-ARMS PCR analysis of angiotensinogen AGT T174M (rs4762) genetic polymorphism in diabetic patients: a comprehensive study.Frontiers in endocrinology · 2023Article
- Article
- The Renin-Angiotensin System: A Key Role in SARS-CoV-2-Induced COVID-19.Molecules (Basel, Switzerland) · 2021Review
- Risk factors for premature coronary artery disease (PCAD) in adults: a systematic review protocol.F1000Research · 2021Article
- Relationship between the Prevalence of ACE1 I/D Polymorphism Genotype II and Covid-19 Morbidity, Mortality in Ukraine and in Some Europe Countries.Cytology and genetics · 2021Article
- ACE Gene Variants Rise the Risk of Severe COVID-19 in Patients With Hypertension, Dyslipidemia or Diabetes: A Spanish Pilot Study.Frontiers in endocrinology · 2021Article
- SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype.Gene · 2020Article
- Angiotensin-converting enzyme gene D-allele and the severity of coronary artery disease.Experimental and therapeutic medicine · 2020Article
- The Association of Hereditary Prothrombotic Risk Factors with ST-Elevation Myocardial Infarction.Medeniyet medical journal · 2020Article
- ACE gene rs4343 polymorphism elevates the risk of preeclampsia in pregnant women.Journal of human hypertension · 2018Article
- Angiotensin-converting enzyme gene rs4343 polymorphism increases susceptibility to migraine.CNS neuroscience & therapeutics · 2017Article
- Renin-angiotensin system gene polymorphisms and coronary artery disease in Saudi patients with diabetes mellitus.International journal of clinical and experimental pathology · 2017Article
- Renin-angiotensin system gene polymorphisms among Saudi patients with coronary artery disease.Journal of biological research (Thessalonike, Greece) · 2014Article
- Association of angiotensin II type I and type II receptor genes polymorphisms with the presence of premature coronary disease and metabolic syndrome.Molecular biology reports · 2014Article
- Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis.Journal of geriatric cardiology : JGC · 2013Article
- Assessment of two missense polymorphisms (rs4762 and rs699) of the angiotensinogen gene and stroke.Experimental and therapeutic medicine · 2013Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral polymorphisms within the renin-angiotensin system cluster of genes have been associated with the advent of coronary artery disease (CAD) or related pathologies. We investigated the distribution of 5 of these polymorphisms in order to find any association with CAD development and distinguish if any of the biochemical and behavioural factors interact with genetic polymorphisms in the advent of the disease.
methodsACE I/D (rs4340), ACE A11860G (rs4343), AT1R A1166C (rs5186), AGT T174M (rs4762) and AGT M235T (rs699) gene polymorphisms were PCR-RFLP analysed in 298 CAD patients and 510 controls from Portugal. Several biochemical and behavioural markers were obtained.
resultsACE I/D DD and ACE11860 GG genotypes are risk factors for CAD in this population. The simultaneous presence of ACE I/D I and ACE11860 A alleles corresponds to a significant trend towards a decrease in CAD incidence. We found several synergistic effects between the studied polymorphisms and classical risk factors such as hypertension, obesity, diabetes and dyslipidaemia: the presence of the DD genotype of ACE I/D (and also ACE11860 GG) increases the odds of developing CAD when associated to each one of these classical risk factors, particularly when considering the male and early onset CAD subgroup analysis; AGT235 TT also increases the CAD risk in the presence of hypertension and dyslipidaemia, and AT1R1166 interacts positively with hypertension, smoking and obesity.
conclusionACE polymorphisms were shown to play a major role in individual susceptibility to develop CAD. There is also a clear interaction between RAS predisposing genes and some biochemical/environmental risk factors in CAD onset, demonstrating a significant enhancement of classical markers particularly by ACE I/D and ACE11860.
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