ArticleNutrition & metabolism2008
Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies.
Article in Nutrition & metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leucine and Skeletal Muscle Disuse: Clinical Anti-Atrophic Effectiveness and Related Mechanisms
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit (STROMA-ICU)
Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- Trial
- Trial
- Treatment with L-type amino acid transporter 1 inhibitor JPH203 enhances protein synthesis in C2C12 myotubes.Scientific reports · 2025Article
- Effects of Branched-chain Amino Acids on Nutritional Metabolism and Pharmacoeconomics in Patients with Severe Abdominal Trauma.Current medical science · 2021Article
- Advances in the Role of Leucine-Sensing in the Regulation of Protein Synthesis in Aging Skeletal Muscle.Frontiers in cell and developmental biology · 2021Review
- Understanding Muscle Protein Dynamics: Technical Considerations for Advancing Sarcopenia Research.Annals of geriatric medicine and research · 2020Article
- Essential Amino Acids (EAA) Mixture Supplementation: Effects of an Acute Administration Protocol on Myoelectric Manifestations of Fatigue in the Biceps Brachii After Resistance Exercise.Frontiers in physiology · 2018Article
- A Moderate Supplementation of Native Whey Protein Promotes Better Muscle Training and Recovery Adaptations Than Standard Whey Protein - A 12-Week Electrical Stimulation and Plyometrics Training Study.Frontiers in physiology · 2018Article
- Targeting Inflammation and Downstream Protein Metabolism in Sarcopenia: A Brief Up-Dated Description of Concurrent Exercise and Leucine-Based Multimodal Intervention.Frontiers in physiology · 2017Review
- Protein Requirements during Aging.Nutrients · 2016Review
- Selective amino acid restriction therapy (SAART): a non-pharmacological strategy against all types of cancer cells.Oncoscience · 2015Article
- DL-2-hydroxyisocaproic acid attenuates inflammatory responses in a murine Candida albicans biofilm model.Clinical and vaccine immunology : CVI · 2014Article
- Beyond the role of dietary protein and amino acids in the prevention of diet-induced obesity.International journal of molecular sciences · 2014Review
- Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes.Journal of nutrition and metabolism · 2014Article
- International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB).Journal of the International Society of Sports Nutrition · 2013Article
- Article
- Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice.Nutrition & metabolism · 2012Article
- Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action.Journal of nutrition and metabolism · 2012Article
- Potential therapeutic effects of branched-chain amino acids supplementation on resistance exercise-based muscle damage in humans.Journal of the International Society of Sports Nutrition · 2011Article
- Exercise x BCAA Supplementation in Young Trained Rats: What are their Effects on Body Growth?Journal of sports science & medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of present review is to describe the effect of leucine supplementation on skeletal muscle proteolysis suppression in both in vivo and in vitro studies. Most studies, using in vitro methodology, incubated skeletal muscles with leucine with different doses and the results suggests that there is a dose-dependent effect. The same responses can be observed in in vivo studies. Importantly, the leucine effects on skeletal muscle protein synthesis are not always connected to the inhibition of skeletal muscle proteolysis. As a matter of fact, high doses of leucine incubation can promote suppression of muscle proteolysis without additional effects on protein synthesis, and low leucine doses improve skeletal muscle protein ynthesis but have no effect on skeletal muscle proteolysis. These research findings may have an important clinical relevancy, because muscle loss in atrophic states would be reversed by specific leucine supplementation doses. Additionally, it has been clearly demonstrated that leucine administration suppresses skeletal muscle proteolysis in various catabolic states. Thus, if protein metabolism changes during different atrophic conditions, it is not surprising that the leucine dose-effect relationship must also change, according to atrophy or pathological state and catabolism magnitude. In conclusion, leucine has a potential role on attenuate skeletal muscle proteolysis. Future studies will help to sharpen the leucine efficacy on skeletal muscle protein degradation during several atrophic states.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.