ArticleClinical and experimental immunology2008
T cell cytokine polarity as a determinant of immunoglobulin A (IgA) glycosylation and the severity of experimental IgA nephropathy.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Sequential administration of paricalcitol followed by IL-17 blockade for progressive refractory IgA nephropathy patients.Scientific reports · 2024Article
- Characterization of T-Cell receptor repertoire in immunoglobulin a nephropathy.Biomarker research · 2024Article
- Molecular Differences in Glomerular Compartment to Distinguish Immunoglobulin A Nephropathy and Lupus Nephritis.Journal of inflammation research · 2024Article
- Immune abnormalities in IgA nephropathy.Clinical kidney journal · 2023Review
- IgA nephropathy associated with Crohn's disease.World journal of methodology · 2023Review
- The Diagnostic and Predictive Significance of Immune-Related Genes and Immune Characteristics in the Occurrence and Progression of IgA Nephropathy.Journal of immunology research · 2022Article
- A Functional Variant rs3093023 inFrontiers in immunology · 2021Article
- The Role of Immune Modulation in Pathogenesis of IgA Nephropathy.Frontiers in medicine · 2020Review
- T cells in IgA nephropathy: role in pathogenesis, clinical significance and potential therapeutic target.Clinical and experimental nephrology · 2019Review
- Quantification of Infectious Sendai Virus Using Plaque Assay.Bio-protocol · 2018Article
- Sendai Virus Propagation Using Chicken Eggs.Bio-protocol · 2018Article
- Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome.Journal of clinical immunology · 2018Review
- B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement.JCI insight · 2017Article
- MicroRNA-155-induced T lymphocyte subgroup drifting in IgA nephropathy.International urology and nephrology · 2017Article
- Effect of Immunosuppressive Drugs on the Changes of Serum Galactose-Deficient IgA1 in Patients with IgA Nephropathy.PloS one · 2016Observational
- Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Henoch-Schönlein purpura nephritis in children.Nature reviews. Nephrology · 2014Review
- Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations.PloS one · 2013Article
- Protective Effect of Stachybotrys microspora Triprenyl Phenol-7on the Deposition of IgA to the Glomerular Mesangium in Nivalenol-induced IgA Nephropathy Using BALB/c Mice.Journal of toxicologic pathology · 2012Article
- Structural correlates of mouse IgA allotypes.Immunogenetics · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Immunoglobulin A (IgA) glycosylation, recognized as an important pathogenic factor in IgA nephropathy (IgAN), is apparently controlled by the polarity of T helper (Th) cytokine responses. To examine the role of cytokine polarity in IgAN, inbred mice were immunized by intraperitoneal priming with inactivated Sendai virus (SeV) emulsified in either complete Freund's adjuvant (CFA) or incomplete Freund's adjuvant (IFA), which promote Th1- or Th2-immune response, respectively, and then boosted identically twice orally with aqueous suspensions of inactivated virus. Next, some mice were challenged intranasally with infectious SeV. Mice primed with CFA or IFA had equal reductions in nasal viral titre relative to non-immune controls, and equally increased serum levels of SeV-specific IgA antibody. Mice primed with CFA showed higher SeV-specific IgG than those with IFA. Splenocytes from mice primed with IFA produced copious amounts of interleukin (IL)-4 and IL-5, but little interferon-gamma and IL-2; those primed with CFA had reciprocal cytokine recall responses. Total serum IgA and especially SeV-specific IgA from mice primed with IFA showed a selective defect in sialylation and galactosylation. Although the frequency and intensity of glomerular deposits and haematuria did not differ, glomerulonephritis in mice primed with IFA and challenged with infectious virus was more severe than in those given CFA, as judged by serum creatinine level. We conclude that the polarity of T cell cytokines controls the pattern of IgA glycosylation and exerts direct or indirect effects on functional glomerular responses to immune complex deposition.
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Registered trials
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