ArticleBrain pathology (Zurich, Switzerland)2009
Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells.
Article in Brain pathology (Zurich, Switzerland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Mesenchymal Stem/Progenitor Cells: The Prospect of Human Clinical Translation.Stem cells international · 2020Review
- Correlation of Musashi-1, Lgr5, and pEGFR expressions in human small intestinal adenocarcinomas.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Primary analysis and screening of microRNAs in gastric cancer side population cells.World journal of gastroenterology · 2015Article
- Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review.Journal of advanced research · 2014Review
- Article
- The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance.EMBO molecular medicine · 2013Article
- Quantification, self-renewal, and genetic tracing of FL1⁺ tumor-initiating cells in a large cohort of human gliomas.Neuro-oncology · 2012Article
- Neuronal stem cells in the central nervous system and in human diseases.Protein & cell · 2012Review
- Neurogenic astrocytes and their glycoconjugates: not just "glue" anymore.Methods in molecular biology (Clifton, N.J.) · 2012Review
- Identity, fate and potential of cells grown as neurospheres: species matters.Stem cell reviews and reports · 2011Article
- Sequential expression of putative stem cell markers in gastric carcinogenesis.British journal of cancer · 2011Article
- Risk factors in the development of stem cell therapy.Journal of translational medicine · 2011Article
- Long-term cultured human neural stem cells undergo spontaneous transformation to tumor-initiating cells.International journal of biological sciences · 2011Article
- Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas.British journal of cancer · 2009Article
- Common astrocytic programs during brain development, injury and cancer.Trends in neurosciences · 2009Article
- Cellular repair strategies in Parkinson's disease.Therapeutic advances in neurological disorders · 2009Article
- Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1.PloS one · 2009Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have found that cellular self-renewal capacity in brain cancer is heterogeneous, with only stem-like cells having this property. A link between adult stem cells and cancer stem cells remains, however, to be shown. Here, we describe the emergence of cancer stem-like cells from in vitro cultured brain stem cells. Adult rat subventricular zone (SVZ) stem cells transformed into tumorigenic cell lines after expansion in vitro. These cell lines maintained characteristic features of stem-like cells expressing Nestin, Musashi-1 and CD133, but continued to proliferate upon differentiation induction. Karyotyping detected multiple acquired chromosomal aberrations, and syngeneic transplantation into the brain of adult rats resulted in malignant tumor formation. Tumors revealed streak necrosis and displayed a neural as well as an undifferentiated phenotype. Deficient downregulation of platelet-derived growth factor (PDGF) receptor alpha was identified as candidate mechanism for tumor cell proliferation, and its knockdown by siRNA resulted in a reduction of cell growth. Our data point to adult brain precursor cells to be transformed in malignancies. Furthermore, in vitro expansion of adult neural stem cells, which will be mandatory for therapeutic strategies in neurological disorders, also harbors the risk for amplifying precursor cells with acquired genetic abnormalities and induction of malignant tumors after transplantation.
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