ArticleJournal of natural medicines2009
Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7.
Article in Journal of natural medicines, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 79 citations in OpenAlex.
- High-Altitude Medicinal Plants as Promising Source of Phytochemical Antioxidants to Combat Lifestyle-Associated Oxidative Stress-Induced Disorders.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Anti-Inflammatory Effects of Hydroethanolic Extract fromJournal of microbiology and biotechnology · 2024Article
- TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses.The EMBO journal · 2023Article
- Multifunctionality ofCurrent issues in molecular biology · 2022Article
- Osthole Regulates Secretion of Pro-Inflammatory Cytokines and Expression ofJournal of inflammation research · 2022Article
- Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice.Frontiers in pharmacology · 2021Article
- Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway.Oxidative medicine and cellular longevity · 2020Review
- Antifungal activity of osthol in vitro and enhancement in vivo through Eudragit S100 nanocarriers.Virulence · 2018Article
- Raging the War Against Inflammation With Natural Products.Frontiers in pharmacology · 2018Review
- Chondroitin Sulfate-Rich Extract of Skate Cartilage Attenuates Lipopolysaccharide-Induced Liver Damage in Mice.Marine drugs · 2017Article
- Neuroprotective Effect of Osthole on Neuron Synapses in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9.Journal of molecular neuroscience : MN · 2016Article
- Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Osthole, a natural coumarin improves cognitive impairments and BBB dysfunction after transient global brain ischemia in C57 BL/6J mice: involvement of Nrf2 pathway.Neurochemical research · 2015Article
- N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein for targeted osthole-loaded delivery to low-density lipoprotein receptor-rich tumors.International journal of nanomedicine · 2014Article
- Evaluation of Antioxidant Activity and Acute Toxicity of Clausena excavata Leaves Extract.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Synthesis and characterization of low-toxicity N-caprinoyl-N-trimethyl chitosan as self-assembled micelles carriers for osthole.International journal of nanomedicine · 2013Article
- Osthole improves synaptic plasticity in the hippocampus and cognitive function of Alzheimer's disease rats via regulating glutamate.Neural regeneration research · 2012Article
- Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages. Isolation of active oxycoumarins was guided by Western blot analysis of iNOS protein expression. These oxycoumarins showed an inhibitory effect on iNOS protein expression at 10 microM. Further examination of the inhibitory effects of these compounds on inflammation mediators revealed that the synthesis of nitric oxide (NO) and the protein expression of tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) were inhibited by 5. It was expected that these compounds show anti-inflammatory activities.
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