ArticleMolecular vision2008
Evaluation of EGR1 as a candidate gene for high myopia.
Article in Molecular vision, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Integrative gene target mapping, RNA sequencing, in silico molecular docking, ADMET profiling and molecular dynamics simulation study of marine derived molecules for type 1 diabetes mellitus.Molecular diversity · 2026Article
- Ginkgo biloba extracts improve choroidal circulation leading to suppression of myopia in mice.Scientific reports · 2023Article
- Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina.Precision clinical medicine · 2021Article
- Genetic background-dependent role ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Controversial opinion: evaluation of EGR1 and LAMA2 loci for high myopia in Chinese populations.Journal of Zhejiang University. Science. B · 2016Article
- Article
- Assessment of exonic single nucleotide polymorphisms in the adenosine A2A receptor gene to high myopia susceptibility in Chinese subjects.Molecular vision · 2011Article
- Sequence variations of GRM6 in patients with high myopia.Molecular vision · 2009Article
- An evaluation of OPTC and EPYC as candidate genes for high myopia.Molecular vision · 2009Article
- Common variant in myocilin gene is associated with high myopia in isolated population of Korcula Island, Croatia.Croatian medical journal · 2009Article
- Clinical and linkage study on a consanguineous Chinese family with autosomal recessive high myopia.Molecular vision · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEGR1 (OMIM 128990) is an early growth response gene that has been shown to be related to myopia by upregulation and down-regulation of axial eye growth in experimentally induced chicken myopia and knockout mice. The purpose of this study was to test whether variations in the human EGR1 gene are related to high myopia.
methodsGenomic DNA was prepared from leukocytes of peripheral blood. Cycle sequencing was used to detect sequence variations in EGR1.
resultsNo pathological mutations were detected upon sequencing of the coding regions and the adjacent intronic regions of EGR1 in 96 unrelated Chinese subjects with high myopia. Only one silent variation, c.1026G>A (p.V342V), was detected in one patients with high myopia, which would not affect the encoded protein. For all 96 subjects, only one allele was detected in each of the three known single nucleotide polymorphisms (SNPs) in EGR1.
conclusionsWe found no evidence that EGR1 is responsible for high myopia in these patients.
Indexed as
Identifiers
18636116PMC2464612W3150431076What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.