ArticleCell death and differentiation2008
The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival.
Article in Cell death and differentiation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Tissue specificity and spatio-temporal dynamics of the p53 transcriptional program.Cell death and differentiation · 2023Review
- Dynamics and consequences of the HTLV-1 proviral plus-strand burst.PLoS pathogens · 2022Article
- MDMX Regulates Transcriptional Activity of p53 and FOXO Proteins to Stimulate Proliferation of Melanoma Cells.Cancers · 2022Article
- Funerals and Feasts: The Immunological Rites of Cell Death.The Yale journal of biology and medicine · 2019Review
- TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.Science translational medicine · 2018Article
- Phaseolus acutifolius Lectin Fractions Exhibit Apoptotic Effects on Colon Cancer: Preclinical Studies Using Dimethilhydrazine or Azoxi-Methane as Cancer Induction Agents.Molecules (Basel, Switzerland) · 2017Article
- Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles.Developmental cell · 2017Article
- p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis.The American journal of pathology · 2017Article
- Mouse modelling of the MDM2/MDMX-p53 signalling axis.Journal of molecular cell biology · 2017Review
- Mdm proteins: critical regulators of embry ogenesis and homeostasis.Journal of molecular cell biology · 2017Review
- MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury.Cell death & disease · 2016Article
- Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes.Journal of the American Society of Nephrology : JASN · 2015Article
- Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.Oncogene · 2015Article
- The p53 control of apoptosis and proliferation: lessons from Drosophila.Apoptosis : an international journal on programmed cell death · 2014Review
- Mdm2 is required for maintenance of the nephrogenic niche.Developmental biology · 2014Article
- Animal models of colorectal cancer.Cancer metastasis reviews · 2013Review
- MDM2, MDMX and p53 in oncogenesis and cancer therapy.Nature reviews. Cancer · 2013Review
- Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation.Cell death and differentiation · 2013Article
- p53 E3 ubiquitin protein ligase homolog regulates p53 in vivo in the adult mouse eye lens.Molecular vision · 2013Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Mdm2 is the major inhibitor of the p53 tumor suppressor. Loss of Mdm2 in mice or in specific tissues of the mouse always yields p53-dependent lethal phenotypes. However, the role of Mdm2 in tissues with high turnover capacity is unknown. We have engineered mice lacking Mdm2 in the intestinal epithelium using the Cre/LoxP system. Loss of Mdm2 (Mdm2(intDelta)) results in viable animals, but neonates display multiple intestinal abnormalities such as hyperplasia, enterocyte vacuolization, and inflammation. These defects correlate with a drastic increase in p53-dependent apoptosis in highly proliferative and differentiated cells. Unexpectedly, the observed phenotypes disappear with age. The tissue selects against Mdm2-null cells and increases its proliferative capacity. Additionally, the intestinal stem and progenitor cell populations are enriched leading to an increase in crypt fission events. Enhanced proliferation is achieved by activation of the canonical Wnt and EGFR-mediated Ras/MAPK pathways. While Mdm2 is a critical inhibitor of p53 in the intestinal epithelium, the tissue employs a series of processes that compensate for cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.