ReviewShock (Augusta, Ga.)2009
Aging and animal models of systemic insult: trauma, burn, and sepsis.
Review in Shock (Augusta, Ga.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Intoxication, inflammaging, and injury: my journey through leukocyte biology.Journal of leukocyte biology · 2026Article
- Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice.Experimental gerontology · 2022Article
- Advanced age exacerbates intestinal epithelial permeability after burn injury in mice.Experimental gerontology · 2022Article
- Small animal models of thermal injury.Methods in cell biology · 2022Review
- Loss ofeLife · 2021Article
- Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention.Signal transduction and targeted therapy · 2021Review
- Burns in the Elderly: Potential Role of Stem Cells.International journal of molecular sciences · 2020Review
- Advanced Age Impairs Intestinal Antimicrobial Peptide Response and Worsens Fecal Microbiome Dysbiosis Following Burn Injury in Mice.Shock (Augusta, Ga.) · 2020Article
- Modelling physical resilience in ageing mice.Mechanisms of ageing and development · 2019Review
- Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing.Advanced drug delivery reviews · 2018Review
- Perioperative inflammatory response in major fracture: do geriatric patients behave differently?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016Article
- Impaired Immune Response in Elderly Burn Patients: New Insights Into the Immune-senescence Phenotype.Annals of surgery · 2016Article
- A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Intestine immune homeostasis after alcohol and burn injury.Shock (Augusta, Ga.) · 2015Review
- A Systematic Review of Rhubarb (a Traditional Chinese Medicine) Used for the Treatment of Experimental Sepsis.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- The systemic immune response to trauma: an overview of pathophysiology and treatment.Lancet (London, England) · 2014Review
- Aging and injury: alterations in cellular energetics and organ function.Aging and disease · 2014Review
- Aging and its Impact on Innate Immunity and Inflammation: Implications for Periodontitis.Journal of oral biosciences · 2014Article
- Toll like receptor signaling in "inflammaging": microRNA as new players.Immunity & ageing : I & A · 2013Article
- Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In the acute-care setting, it is widely accepted that elderly patients have increased morbidity and mortality compared with young healthy patients. The reasons for this, however, are largely unknown. Although animal modeling has helped improve treatment strategies for young patients, there are a scarce number of studies attempting to understand the mechanisms of systemic insults such as trauma, burn, and sepsis in aged individuals. This review aims to highlight the relevance of using animals to study the pathogenesis of these insults in the aged and, despite the deficiency of information, to summarize what is currently known in this field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.