ArticleAmerican journal of respiratory cell and molecular biology2009
Acute exercise decreases airway inflammation, but not responsiveness, in an allergic asthma model.
Article in American journal of respiratory cell and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- The Impact of Meal Dietary Inflammatory Index on Exercise-Induced Changes in Airway Inflammation in Adults with Asthma.Nutrients · 2022Trial
- The Microbiota and Equine Asthma: An Integrative View of the Gut-Lung Axis.Animals : an open access journal from MDPI · 2024Review
- Defining a role for exercise training in the management of asthma.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Anti-oxidant and Anti-inflammatory Effects of Aquatic Exercise in Allergic Airway Inflammation in Mice.Frontiers in physiology · 2019Article
- Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung Injury.Antioxidants & redox signaling · 2016Article
- Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway.Frontiers in immunology · 2016Article
- Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Exercise and asthma: an overview.European clinical respiratory journal · 2015Article
- Evaluation of immune response after moderate and overtraining exercise in wistar rat.Iranian journal of basic medical sciences · 2014Article
- Exercise training, lymphocyte subsets and their cytokines production: experience of an Italian professional football team and their impact on allergy.BioMed research international · 2014Article
- Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation.Molecular immunology · 2013Article
- Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lung.Brain, behavior, and immunity · 2013Article
- Obesity in asthma: approaches to treatment.Current allergy and asthma reports · 2013Review
- S100A12 and the Airway Smooth Muscle: Beyond Inflammation and Constriction.Journal of allergy & therapy · 2012Article
- Rapid morphological characterization of isolated mitochondria using Brownian motion.Analytical methods : advancing methods and applications · 2012Article
- Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice.PloS one · 2012Article
- Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice.American journal of respiratory cell and molecular biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have suggested that the asthmatic responses of airway inflammation, remodeling, and hyperresponsiveness (AHR) are interrelated; in this study, we used exercise to examine the nature of this interrelationship. Mice were sensitized and challenged with ovalbumin (OVA); mice were then exercised via running on a motorized treadmill at a moderate intensity. Data indicate that, within the lungs of OVA-treated mice, exercise attenuated the production of inflammatory mediators, including chemokines KC, RANTES, and MCP-1 and IL-12p40/p80. Coordinately, OVA-treated and exercised mice displayed decreases in leukocyte infiltration, including eosinophils, as compared with sedentary controls. Results also show that a single bout of exercise significantly decreased phosphorylation of the NFkappaB p65 subunit, which regulates the gene expression of a wide variety of inflammatory mediators. In addition, OVA-treated and exercised mice exhibited decreases in the levels of Th2-derived cytokines IL-5 and IL-13 and the prostaglandin PGE(2), as compared with sedentary controls. In contrast, results show that a single bout of exercise had no effect on AHR in OVA-treated mice challenged with increasing doses of aerosolized methacholine (0-50 mg/ml) as compared with sedentary mice. Exercise also had no effect on epithelial cell hypertrophy, mucus production, or airway wall thickening in OVA-treated mice as compared with sedentary controls. These findings suggest that a single bout of aerobic exercise at a moderate intensity attenuates airway inflammation but not AHR or airway remodeling in OVA-treated mice. The implication of these findings for the interrelationship between airway inflammation, airway remodeling, and AHR is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.