ArticleThe Journal of physiology2008
Monosynaptic convergence of C- and Adelta-afferent fibres from different segmental dorsal roots on to single substantia gelatinosa neurones in the rat spinal cord.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
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- Contralateral Afferent Input to Lumbar Lamina I Neurons as a Neural Substrate for Mirror-Image Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The structure of sensory afferent compartments in health and disease.Journal of anatomy · 2022Review
- Presynaptic Interactions between Trigeminal and Cervical Nociceptive Afferents Supplying Upper Cervical Lamina I Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Elucidating afferent-driven presynaptic inhibition of primary afferent input to spinal laminae I and X.Frontiers in cellular neuroscience · 2022Article
- Needling Interventions for Sciatica: Choosing Methods Based on Neuropathic Pain Mechanisms-A Scoping Review.Journal of clinical medicine · 2021Article
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- Distinct mechanisms of signal processing by lamina I spino-parabrachial neurons.Scientific reports · 2019Article
- Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice.Nature communications · 2019Article
- Assessment of axonal recruitment using model-guided preclinical spinal cord stimulation in the ex vivo adult mouse spinal cord.Journal of neurophysiology · 2019Article
- Unique Characteristics of the Dorsal Root Ganglion as a Target for Neuromodulation.Pain medicine (Malden, Mass.) · 2019Review
- Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A-Type KFrontiers in molecular neuroscience · 2018Review
- Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits and motor impairment.Aging cell · 2016Article
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- Aberrant synaptic integration in adult lamina I projection neurons following neonatal tissue damage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses.The Journal of physiology · 2014Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Although it is known that each spinal cord segment receives thin-fibre inputs from several segmental dorsal roots, it remains unclear how these inputs converge at the cellular level. To study whether C- and Adelta-afferents from different roots can converge monosynaptically on to a single substantia gelatinosa (SG) neurone, we performed tight-seal recordings from SG neurones in the entire lumbar enlargement of the rat spinal cord with all six segmental (L1-L6) dorsal roots attached. The neurones in the spinal cord were visualized using our recently developed oblique LED illumination technique. Individual SG neurones from the spinal segment L4 or L3 were voltage clamped to record the monosynaptic EPSCs evoked by stimulating ipsilateral L1-L6 dorsal roots. We found that one-third of the SG neurones receive simultaneous monosynaptic inputs from two to four different segmental dorsal roots. For the SG neurones from segment L4, the major monosynaptic input was from the L4-L6 roots, whereas for those located in segment L3 the input pattern was shifted to the L2-L5 roots. Based on these data, we propose a new model of primary afferent organization where several C- or Adelta-fibres innervating one cutaneous region (peripheral convergence) and ascending together in a common peripheral nerve may first diverge at the level of spinal nerves and enter the spinal cord through different segmental dorsal roots, but finally re-converge monosynaptically on to a single SG neurone. This organization would allow formation of precise and robust neural maps of the body surface at the spinal cord level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.