ArticleThe Journal of physiology2008
Role of the commissural inhibitory system in vestibular compensation in the rat.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 82 citations in OpenAlex.
- Developmental timing of auditory deprivation influences spatial memory and hippocampal plasticity in rats.Scientific reports · 2025Article
- Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation.Molecular neurobiology · 2024Review
- Advanced progress of vestibular compensation in vestibular neural networks.CNS neuroscience & therapeutics · 2024Review
- Molecular profile of vestibular compensation in the medial vestibular nucleus after unilateral labyrinthectomy.Journal of cellular and molecular medicine · 2024Article
- The Vestibular Nuclei: A Cerebral Reservoir of Stem Cells Involved in Balance Function in Normal and Pathological Conditions.International journal of molecular sciences · 2024Review
- The Nature and Origin of Synaptic Inputs to Vestibulospinal Neurons in the Larval Zebrafish.eNeuro · 2023Article
- Differential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation.Biomedicines · 2023Article
- The nature and origin of synaptic inputs to vestibulospinal neurons in the larval zebrafish.bioRxiv : the preprint server for biology · 2023Article
- Redistribution of the astrocyte phenotypes in the medial vestibular nuclei after unilateral labyrinthectomy.Frontiers in neuroscience · 2023Article
- Parvalbumin-positive neurons in the medial vestibular nucleus contribute to vestibular compensation through commissural inhibition.Frontiers in cellular neuroscience · 2023Article
- Dose- and application route-dependent effects of betahistine on behavioral recovery and neuroplasticity after acute unilateral labyrinthectomy in rats.Frontiers in neurology · 2023Article
- Perinatal development of central vestibular neurons in mice.Frontiers in neuroscience · 2022Article
- Whole-brain monosynaptic outputs and presynaptic inputs of GABAergic neurons in the vestibular nuclei complex of mice.Frontiers in neuroscience · 2022Article
- Effect and mechanism of BDNF/TrkB signaling on vestibular compensation.Bioengineered · 2021Article
- Repeated Galvanic Vestibular Stimulation Modified the Neuronal Potential in the Vestibular Nucleus.Neural plasticity · 2020Article
- Histamine H1 Receptor Contributes to Vestibular Compensation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Association of the Video Head Impulse Test With Improvement of Dynamic Balance and Fall Risk in Patients With Dizziness.JAMA otolaryngology-- head & neck surgery · 2018Article
- Surgical Labyrinthectomy of the Rat to Study the Vestibular System.Journal of visualized experiments : JoVE · 2018Article
- MicroRNAs 218a-5p, 219a-5p, and 221-3p regulate vestibular compensation.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the role of the vestibular commissural inhibitory system in vestibular compensation (VC, the behavioural recovery that follows unilateral vestibular loss), using in vivo microdialysis to measure GABA levels in the bilateral medial vestibular nucleus (MVN) at various times after unilateral labyrinthectomy (UL). Immediately after UL, in close correlation with the appearance of the characteristic oculomotor and postural symptoms, there is a marked increase in GABA release in the ipsi-lesional MVN. This is not prevented by bilateral flocculectomy, indicating that it is due to hyperactivity of vestibular commissural inhibitory neurones. Over the following 96 h, as VC occurs and the behavioural symptoms ameliorate, the ipsi-lesional GABA levels return to near-normal. Contra-lesional GABA levels do not change significantly in the initial stages of VC, but decrease at late stages so that when static symptoms have abated there remains a significant difference between the MVNs of the two sides. We also investigated the role of the commissural inhibition in Bechterew's phenomenon, by reversibly inactivating the intact contra-lesional labyrinth in compensating animals through superfusion of local anaesthetic on the round window. Transient inactivation of the intact labyrinth elicited the lateralized behaviour described by Bechterew, but did not alter the GABA levels in either MVN, suggesting the involvement of distinct cellular mechanisms. These findings indicate that an imbalanced commissural inhibitory system is a root cause of the severe oculomotor and postural symptoms of unilateral vestibular loss, and that re-balancing of commissural inhibition occurs in parallel with the subsequent behavioural recovery during VC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.