ArticleAJNR. American journal of neuroradiology2008
Dynamic perfusion CT assessment of the blood-brain barrier permeability: first pass versus delayed acquisition.
Article in AJNR. American journal of neuroradiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Quantitative CT perfusion imaging in patients with pancreatic cancer: a systematic review.Abdominal radiology (New York) · 2022Pooled it
- Recombinant tissue plasminogen activator increases blood-brain barrier disruption in acute ischemic stroke: an MR imaging permeability study.AJNR. American journal of neuroradiology · 2009Trial
- Blood-Brain Barrier Disruption and Imaging Assessment in Stroke.Translational stroke research · 2025Review
- Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective.Frontiers in aging neuroscience · 2023Review
- Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment in Acute Ischemic Stroke.Cellular and molecular neurobiology · 2022Review
- Reperfusion facilitates reversible disruption of the human blood-brain barrier following acute ischaemic stroke.European radiology · 2018Article
- Severe Blood-Brain Barrier Disruption in Cardioembolic Stroke.Frontiers in neurology · 2018Article
- Multimodality imaging of blood-brain barrier impairment during epileptogenesis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Carotid Artery Stenting and Blood-Brain Barrier Permeability in Subjects with Chronic Carotid Artery Stenosis.International journal of molecular sciences · 2017Article
- Application of Blood-Brain Barrier Permeability Imaging in Global Cerebral Edema.AJNR. American journal of neuroradiology · 2016Article
- Blood-brain barrier permeability imaging using perfusion computed tomography.Radiology and oncology · 2015Review
- Radiochemotherapy-induced changes of tumour vascularity and blood supply estimated by dynamic contrast-enhanced CT and fractal analysis in malignant head and neck tumours.The British journal of radiology · 2015Article
- Improving low-dose blood-brain barrier permeability quantification using sparse high-dose induced prior for Patlak model.Medical image analysis · 2014Article
- Prediction of outcome in patients with suspected acute ischaemic stroke with CT perfusion and CT angiography: the Dutch acute stroke trial (DUST) study protocol.BMC neurology · 2014Observational
- Drug delivery to the ischemic brain.Advances in pharmacology (San Diego, Calif.) · 2014Review
- A fast nonlinear regression method for estimating permeability in CT perfusion imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Determination of vascular permeability coefficients under slow luminal filling.Microvascular research · 2013Article
- Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications.Journal of pharmacokinetics and pharmacodynamics · 2013Review
- Quantification of blood-to-brain transfer rate in multiple sclerosis.Multiple sclerosis and related disorders · 2013Article
- Measurement of blood-brain barrier permeability in acute ischemic stroke using standard first-pass perfusion CT data.NeuroImage. Clinical · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
background and purposeThe Patlak model has been applied to first-pass perfusion CT (PCT) data to extract information on blood-brain barrier permeability (BBBP) to predict hemorrhagic transformation in patients with acute stroke. However, the Patlak model was originally described for the delayed steady-state phase of contrast circulation. The goal of this study was to assess whether the first pass or the delayed phase of a contrast bolus injection better respects the assumptions of the Patlak model for the assessment of BBBP in patients with acute stroke by using PCT. MATERIALS AND
methodsWe retrospectively identified 125 consecutive patients (29 with acute hemispheric stroke and 96 without) who underwent a PCT study by using a prolonged acquisition time up to 3 minutes. The Patlak model was applied to calculate BBBP in ischemic and nonischemic brain tissue. Linear regression of the Patlak plot was performed separately for the first pass and for the delayed phase of the contrast bolus injection. Patlak linear regression models for the first pass and the delayed phase were compared in terms of their respective square root mean squared errors (square root MSE) and correlation coefficients (R) by using generalized estimating equations with robust variance estimation.
resultsBBBP values calculated from the first pass were significantly higher than those from the delayed phase, both in nonischemic brain tissue (2.81 mL x 100 g(-1) x min(-1) for the first pass versus 1.05 mL x 100 g(-1) x min(-1) for the delayed phase, P < .001) and in ischemic tissue (7.63 mL x 100 g(-1) x min(-1) for the first pass versus 1.31 mL x 100 g(-1) x min(-1) for the delayed phase, P < .001). Compared with regression models from the first pass, Patlak regression models obtained from the delayed data were of better quality, showing significantly lower square root MSE and higher R.
conclusionOnly the delayed phase of PCT acquisition respects the assumptions of linearity of the Patlak model in patients with and without stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.