ArticleDevelopment (Cambridge, England)2008
BMP2 and BMP7 play antagonistic roles in feather induction.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 97 citations in OpenAlex.
- Opposing roles for Bmp signalling during the development of electrosensory lateral line organs.eLife · 2025Article
- Patterning in stratified epithelia depends on cell-cell adhesion.Life science alliance · 2024Article
- How a reaction-diffusion signal can control spinal cord regeneration in axolotls: A modeling study.iScience · 2024Article
- A chromosome-level genome assembly of the Asian house martin implies potential genes associated with the feathered-foot trait.G3 (Bethesda, Md.) · 2024Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- Novel Aspects in Pattern Formation Arise from Coupling Turing Reaction-Diffusion and Chemotaxis.Bulletin of mathematical biology · 2023Article
- Review
- Evo Devo of the Vertebrates Integument.Journal of developmental biology · 2023Review
- Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo.Science advances · 2023Article
- Cell shape anisotropy contributes to self-organized feather pattern fidelity in birds.PLoS biology · 2022Article
- Functional Differentiation of BMP7 Genes in Zebrafish:Frontiers in cell and developmental biology · 2022Article
- Size matters: tissue size as a marker for a transition between reaction-diffusion regimes in spatio-temporal distribution of morphogens.Royal Society open science · 2022Article
- Perturbation analysis of a multi-morphogen Turing reaction-diffusion stripe patterning system reveals key regulatory interactions.Development (Cambridge, England) · 2020Article
- Recent Advances in Biomaterials for the Treatment of Bone Defects.Organogenesis · 2020Review
- The role of CTNNB1 and LEF1 in feather follicles development of Anser cygnoides and Anser anser.Genes & genomics · 2020Article
- Sonic hedgehog specifies flight feather positional information in avian wings.Development (Cambridge, England) · 2020Article
- Symmetry breaking in the embryonic skin triggers directional and sequential plumage patterning.PLoS biology · 2019Article
- Article
- Turing patterning with and without a global wave.PLoS biology · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feathers, like hairs, first appear as primordia consisting of an epidermal placode associated with a dermal condensation that is necessary for the continuation of their differentiation. Previously, the BMPs have been proposed to inhibit skin appendage formation. We show that the function of specific BMPs during feather development is more complex. BMP2 and BMP7, which are expressed in both the epidermis and the dermis, are involved in an antagonistic fashion in regulating the formation of dermal condensations, and thus are both necessary for subsequent feather morphogenesis. BMP7 is expressed earlier and functions as a chemoattractant that recruits cells into the condensation, whereas BMP2 is expressed later, and leads to an arrest of cell migration, likely via its modulation of the EIIIA fibronectin domain and alpha4 integrin expression. Based on the observed cell proliferation, chemotaxis and the timing of BMP2 and BMP7 expression, we propose a mathematical model, a reaction-diffusion system, which not only simulates feather patterning, but which also can account for the negative effects of excess BMP2 or BMP7 on feather formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.