ReviewAnesthesia and analgesia2008
Sex, gender, and pain: an overview of a complex field.
Review in Anesthesia and analgesia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review and Meta-Analysis of 12 Randomized Controlled Trials Evaluating the Efficacy of Invasive Radiofrequency Treatment for Knee Pain and Function.BioMed research international · 2019Pooled it
- Remifentanil requirement for i-gel insertion is reduced in male patients with Parkinson's disease undergoing deep brain stimulator implantation: an up-and-down sequential allocation trial.BMC anesthesiology · 2022Trial
- Trial
- A Pilot Study on Bioactive Constituents and Analgesic Effects of MyrLiq®, aBioMed research international · 2017Trial
- Trial
- Back pain in seniors: the Back pain Outcomes using Longitudinal Data (BOLD) cohort baseline data.BMC musculoskeletal disorders · 2014Trial
- Effect of buspirone on thermal sensory and pain thresholds in human volunteers.BMC clinical pharmacology · 2009Trial
- Opioid and Stimulant Coprescriptions among South Carolina Residents.Southern medical journal · 2026Article
- Influence of sex and gonadal hormones on pain perception in a neuropathic pain model in old rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Stress induces distinct social behavior states encoded by the ventral hippocampus.bioRxiv : the preprint server for biology · 2025Article
- Ten days of supplementation with a standardizedFrontiers in sports and active living · 2025Article
- Intranasal administration of recombinant human BDNF as a potential therapy for some primary headaches.The journal of headache and pain · 2024Article
- Matching males and females undergoing non mesh primary unilateral inguinal hernia repair: evaluating sex differences in preoperative and acute postoperative pain.Updates in surgery · 2024Article
- Article
- URB937 Prevents the Development of Mechanical Allodynia in Male Rats with Trigeminal Neuralgia.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Unmasking the Adverse Impacts of Sex Bias on Science and Research Animal Welfare.Animals : an open access journal from MDPI · 2023Review
- Sex and gender differences in healthcare utilisation trajectories: a cohort study among Quebec workers living with chronic pain.BMJ open · 2023Article
- Promoting Inclusion, Diversity, and Equity in Pain Science.The Clinical journal of pain · 2023Article
- Promoting Inclusion, Diversity, and Equity in Pain Science.Pain medicine (Malden, Mass.) · 2023Article
- Effect of ImmatureMedicina (Kaunas, Lithuania) · 2023Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Traditionally, biomedical research in the field of pain has been conducted with male animals and subjects. Over the past 20-30 yr, it has been increasingly recognized that this narrow approach has missed an important variable: sex. An ever-increasing number of studies have established sex differences in response to pain and analgesics. These studies have demonstrated that the differences between the sexes appear to have a biological and psychological basis. We will provide brief review of the epidemiology, rodent, and human experimental findings. The controversies and widespread disagreement in the literature highlight the need for a progressive approach to the questions involving collaborative efforts between those trained in the basic and clinical biomedical sciences and those in the epidemiological and social sciences. In order for patients suffering from acute and/or chronic pain to benefit from this work, the approach has to involve the use or development of clinically relevant models of nociception or pain to answer the basic, but complex, question. The present state of the literature allows no translation of the work to our clinical decision-making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.