ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis.Frontiers in immunology · 2024Review
- Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation.The Journal of experimental medicine · 2021Article
- Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation.The Journal of endocrinology · 2020Article
- Sensory denervation of inguinal white fat modifies sympathetic outflow to white and brown fat in Siberian hamsters.Physiology & behavior · 2018Article
- Separate and shared sympathetic outflow to white and brown fat coordinately regulates thermoregulation and beige adipocyte recruitment.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Brown adipose tissue: physiological function and evolutionary significance.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- Brown adipose tissue has sympathetic-sensory feedback circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Distinct networks of leptin- and insulin-sensing neurons regulate thermogenic responses to nutritional and cold challenges.Diabetes · 2015Article
- Neural innervation of white adipose tissue and the control of lipolysis.Frontiers in neuroendocrinology · 2014Review
- Central nervous system regulation of brown adipose tissue.Comprehensive Physiology · 2014Review
- Central sympathetic innervations to visceral and subcutaneous white adipose tissue.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance.Cell metabolism · 2012Review
- The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes.Journal of lipid research · 2012Article
- Central control of brown adipose tissue thermogenesis.Frontiers in endocrinology · 2012Article
- Sympathetic and sensory innervation of brown adipose tissue.International journal of obesity (2005) · 2010Review
- Multiple thermoregulatory effectors with independent central controls.European journal of applied physiology · 2010Review
- 2-Deoxy-D-glucose, but not mercaptoacetate, increases food intake in decerebrate rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Testosterone replacement does not normalize carcass composition in chronically decerebrate male rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance.Endocrinology · 2009Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Hypothalamic neurons are regarded as essential for integrating thermal afferent information from skin and core and issuing commands to autonomic and behavioral effectors that maintain core temperature (T(c)) during cold exposure and for the control of energy expenditure more generally. Caudal brain stem neurons are necessary elements of the hypothalamic effector pathway and also are directly driven by skin and brain cooling. To assess whether caudal brain stem processing of thermal afferent signals is sufficient to drive endemic effectors for thermogenesis, heart rate (HR), T(c), and activity responses of chronic decerebrate (CD) and control rats adapted to 23 degrees C were compared during cold exposure (4, 8, or 12 degrees C) for 6 h. Other CDs and controls were exposed to 4 or 23 degrees C for 2 h, and tissues were processed for norepinephrine turnover (NETO), a neurochemical measure of sympathetic drive. Controls maintained T(c) for all temperatures. CDs maintained T(c) for the 8 and 12 degrees C exposures, but T(c) declined 2 degrees C during the 4 degrees C exposure. Cold exposure elevated HR in CDs and controls alike. Tachycardia magnitude correlated with decreases in environmental temperature for controls, but not CDs. Cold increased NETO in brown adipose tissue, heart, and some white adipose tissue pads in CDs and controls compared with their respective room temperature controls. These data demonstrate that, in neural isolation from the hypothalamus, cold exposure drives caudal brain stem neuronal activity and engages local effectors that trigger sympathetic energetic and cardiac responses that are comparable in many, but not in all, respects to those seen in neurologically intact rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.