ArticleBiomaterials2008
3D imaging of tissue integration with porous biomaterials.
Article in Biomaterials, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 84 citations in OpenAlex.
- In vivo validation of multimodality pore-network modeling to identify angio-permissive scaffold porosity.Materials today. Bio · 2026Article
- An innovative intramedullary bone graft harvesting concept as a fundamental component of scaffold-guided bone regeneration: A preclinicalJournal of orthopaedic translation · 2024Article
- Quality control methods in musculoskeletal tissue engineering: from imaging to biosensors.Bone research · 2021Review
- Photoacoustic Imaging in Tissue Engineering and Regenerative Medicine.Tissue engineering. Part B, Reviews · 2020Review
- Ex Vivo and In Vivo Biocompatibility Assessment (Blood and Tissue) of Three-Dimensional Bacterial Nanocellulose Biomaterials for Soft Tissue Implants.Scientific reports · 2019Article
- [In vivo study of 3D printed porous tantalum implant on osseointegration].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018Article
- Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair.Journal of visualized experiments : JoVE · 2017Article
- Vasculogenic potential evaluation of bottom-up, PCL scaffolds guiding early angiogenesis in tissue regeneration.Journal of materials science. Materials in medicine · 2016Article
- Development of a High-Throughput Ultrasound Technique for the Analysis of Tissue Engineering Constructs.Annals of biomedical engineering · 2016Article
- Hydrogels That Allow and Facilitate Bone Repair, Remodeling, and Regeneration.Journal of materials chemistry. B · 2015Article
- Effect of surface roughness on osteogenesis in vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone-nanohydroxyapatite composite.International journal of nanomedicine · 2015Article
- Three-dimensional characterization of tissue-engineered constructs by contrast-enhanced nanofocus computed tomography.Tissue engineering. Part C, Methods · 2014Article
- Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo.Advanced materials (Deerfield Beach, Fla.) · 2014Article
- Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size.Tissue engineering. Part B, Reviews · 2013Review
- Imaging challenges in biomaterials and tissue engineering.Biomaterials · 2013Article
- The effects of zoledronic acid in the bone and vasculature support of hematopoietic stem cell niches.Journal of cellular biochemistry · 2013Article
- Building vascular networks.Science translational medicine · 2012Review
- Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis.Cancer research · 2012Article
- Article
- Bone tissue engineering: recent advances and challenges.Critical reviews in biomedical engineering · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Porous biomaterials designed to support cellular infiltration and tissue formation play a critical role in implant fixation and engineered tissue repair. The purpose of this Leading Opinion Paper is to advocate the use of high resolution 3D imaging techniques as a tool to quantify extracellular matrix formation and vascular ingrowth within porous biomaterials and objectively compare different strategies for functional tissue regeneration. An initial over-reliance on qualitative evaluation methods may have contributed to the false perception that developing effective tissue engineering technologies would be relatively straightforward. Moreover, the lack of comparative studies with quantitative metrics in challenging pre-clinical models has made it difficult to determine which of the many available strategies to invest in or use clinically for companies and clinicians, respectively. This paper will specifically illustrate the use of microcomputed tomography (micro-CT) imaging with and without contrast agents to nondestructively quantify the formation of bone, cartilage, and vasculature within porous biomaterials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.