ArticleJournal of structural biology2008
Molecular and morphological adaptations in compressed articular cartilage by polarized light microscopy and Fourier-transform infrared imaging.
Article in Journal of structural biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Structural differences between immature and mature articular cartilage of rabbits by microscopic MRI and polarized light microscopy.Journal of anatomy · 2022Article
- Structural Morphology of Rabbit Patella and Suprapatella Cartilage by Microscopic MRI and Polarized Light Microscopy.Cartilage · 2021Article
- Quantitative µMRI and PLM study of rabbit humeral and femoral head cartilage at sub-10 µm resolutions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Simultaneous tractography and elastography imaging of the zone-specific structural and mechanical responses in articular cartilage under compressive loading.Biomedical optics express · 2019Article
- Functional properties of chondrocytes and articular cartilage using optical imaging to scanning probe microscopy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Diffusion tensor imaging of articular cartilage at 3T correlates with histology and biomechanics in a mechanical injury model.Magnetic resonance in medicine · 2017Article
- Loading-induced changes on topographical distributions of the zonal properties of osteoarthritic tibial cartilage--A study by magnetic resonance imaging at microscopic resolution.Journal of biomechanics · 2015Article
- Monitoring the Progression of Spontaneous Articular Cartilage Healing with Infrared Spectroscopy.Cartilage · 2015Article
- Proteoglycan concentrations in healthy and diseased articular cartilage by Fourier transform infrared imaging and principal component regression.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2014Article
- Structure-function relations and rigidity percolation in the shear properties of articular cartilage.Biophysical journal · 2014Article
- Quantitative zonal differentiation of articular cartilage by microscopic magnetic resonance imaging, polarized light microscopy, and Fourier-transform infrared imaging.Microscopy research and technique · 2013Article
- Fourier-transform infrared spectroscopic imaging of articular cartilage and biomaterials: A review.Trends in applied spectroscopy · 2013Article
- MRI of articular cartilage at microscopic resolution.Bone & joint research · 2013Article
- Concentration profiles of collagen and proteoglycan in articular cartilage by Fourier transform infrared imaging and principal component regression.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2012Article
- Depth-dependent Anisotropy of Proteoglycan in Articular Cartilage by Fourier Transform Infrared Imaging.Vibrational Spectroscopy · 2011Article
- Chemical visualization of individual chondrocytes in articular cartilage by attenuated-total-reflection Fourier Transform Infrared Microimaging.Biomedical optics express · 2011Article
- Depth-dependent anisotropies of amides and sugar in perpendicular and parallel sections of articular cartilage by Fourier transform infrared imaging.Microscopy research and technique · 2011Article
- Quantitative determination of morphological and territorial structures of articular cartilage from both perpendicular and parallel sections by polarized light microscopy.Connective tissue research · 2011Article
- Macromolecular concentrations in bovine nasal cartilage by Fourier transform infrared imaging and principal component regression.Applied spectroscopy · 2010Article
- The collagen fibril structure in the superficial zone of articular cartilage by microMRI.Osteoarthritis and cartilage · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Fifteen articular cartilage-bone specimens from one canine humeral joint were compressed in the strain range of 0-50%. The deformation of the extracellular matrices in cartilage was preserved and the same tissue sections were studied using polarized light microscopy (PLM) and Fourier-transform infrared imaging (FTIRI). The PLM results show that the most significant changes in the apparent zone thickness due to 'reorganization' of the collagen fibrils based on the birefringence occur between 0% and 20% strain values, where the increase in the superficial zone and decrease in the radial zone thicknesses are approximately linear with the applied strain. The FTIRI anisotropy results show that the two amide components with bond direction perpendicular to the external compression retain anisotropy (amide II in the superficial zone and amide I in the radial zone). In contrast, the measured anisotropy from the two amide components with bond direction parallel to the external compression changes their anisotropy significantly (amide I in the superficial zone and amide II in the radial zone). Statistical analysis shows that there is an excellent correlation (r=0.98) between the relative depth of the minimum retardance in PLM and the relative depth of the amide II anisotropic cross-over. The changes in amide anisotropies in different histological zones are explained by the strain-dependent tipping angle of the amide bonds. These depth-dependent adaptations to static loading in cartilage's morphological structure and chemical distribution could be useful in the future studies of the early diseased cartilage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.