ArticleNeuropharmacology2009
Critical role for TARPs in early development despite broad functional redundancy.
Article in Neuropharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites.Nature communications · 2023Article
- Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex.Cell reports · 2022Article
- AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions.Nature communications · 2021Article
- AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking.Cellular and molecular life sciences : CMLS · 2019Review
- Regulatory Architecture of the Neuronal Cacng2/Tarpγ2 Gene Promoter: Multiple Repressive Domains, a Polymorphic Regulatory Short Tandem Repeat, and Bidirectional Organization with Co-regulated lncRNAs.Journal of molecular neuroscience : MN · 2019Article
- LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus.Nature communications · 2018Article
- Article
- Activity- and development-dependent down-regulation of TARPγ8 and GluA1 in cultured rat hippocampal neurons.Acta pharmacologica Sinica · 2016Article
- Stargazin promotes closure of the AMPA receptor ligand-binding domain.The Journal of general physiology · 2014Article
- Review
- Transmembrane AMPA receptor regulatory protein (TARP) dysregulation in anterior cingulate cortex in schizophrenia.Schizophrenia research · 2013Article
- Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons.Nature neuroscience · 2013Article
- Interacting partners of AMPA-type glutamate receptors.Journal of molecular neuroscience : MN · 2012Review
- The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits.Current opinion in neurobiology · 2012Review
- Defined criteria for auxiliary subunits of glutamate receptors.The Journal of physiology · 2012Review
- The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits.Neuron · 2011Review
- Stargazin (TARP gamma-2) is required for compartment-specific AMPA receptor trafficking and synaptic plasticity in cerebellar stellate cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transmembrane AMPA receptor regulatory proteins (TARPs), including gamma-2, gamma-3, gamma-4, and gamma-8, are auxiliary subunits for AMPA receptors. Based on studies in single knockout mice, it has been suggested that nearly all native AMPA receptors are associated with TARPs. To study the interplay between TARP family members and AMPA receptors in vivo, we generated mice lacking multiple TARPs. Triple knockout mice lacking gamma-3, gamma-4, and gamma-8 are viable and fertile, and synaptic AMPA receptor activity is reduced to a level comparable to that seen in gamma-8 single knockout mice. In contrast, triple knockout mice lacking gamma-2, gamma-3, and either gamma-4 or gamma-8 cannot survive ex utero. In particular, gamma-2, gamma-3, gamma-4 triple knockout mice are born apneic and paralyzed, despite normal AMPA receptor function in cortical and spinal neurons. We found that gamma-8 is expressed at low levels in early postnatal mice and regulates AMPA receptor levels at this developmental time period. Thus, the early expression of gamma-8 may be responsible for maintaining AMPA receptor functions in neonatal neurons. Together, our data indicate that TARPs, in particular gamma-2, are essential for early development, and that most neurons express multiple members of this functionally redundant protein family.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.