ReviewBrain research2008
Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.
Review in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Theta oscillations are sensitive to both early and late conflict processing stages: effects of alcohol intoxication.PloS one · 2012Trial
- Article
- The collaborative study on the genetics of alcoholism: Brain function.Genes, brain, and behavior · 2023Review
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior.Molecular psychiatry · 2021Article
- Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity.Brain and behavior · 2021Article
- Rich Club Characteristics of Alcohol-Naïve Functional Brain Networks Predict Future Drinking Phenotypes in Rhesus Macaques.Frontiers in behavioral neuroscience · 2021Article
- Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach.Journal of psychopharmacology (Oxford, England) · 2019Article
- High-intensity binge drinking is associated with alterations in spontaneous neural oscillations in young adults.Alcohol (Fayetteville, N.Y.) · 2018Article
- Human Genomic Signatures of Brain Oscillations During Memory Encoding.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Genetic correlates of the development of theta event related oscillations in adolescents and young adults.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.Pharmacogenomics · 2016Article
- Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2015Article
- Gender modulates the development of theta event related oscillations in adolescents and young adults.Behavioural brain research · 2015Article
- Disentangling the impacts of outcome valence and outcome frequency on the post-error slowing.Scientific reports · 2015Article
- Endophenotypes for Alcohol Use Disorder: An Update on the Field.Current addiction reports · 2015Article
- Advances in Electrophysiological Research.Alcohol research : current reviews · 2015Review
- Genetics of alcoholism.Current psychiatry reports · 2014Review
- Does electroencephalogram phase variability account for reduced P3 brain potential in externalizing disorders?Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2014Article
- Oscillatory spatial profile of alcohol's effects on the resting state: anatomically-constrained MEG.Alcohol (Fayetteville, N.Y.) · 2014Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Brain oscillations provide a rich source of potentially useful endophenotypes (intermediate phenotypes) for psychiatric genetics, as they represent important correlates of human information processing and are associated with fundamental processes from perception to cognition. These oscillations are highly heritable, are modulated by genes controlling neurotransmitters in the brain, and provide links to associative and integrative brain functions. These endophenotypes represent traits that are less complex and more proximal to gene function than either diagnostic labels or traditional cognitive measures, providing a powerful strategy in searching for genes in psychiatric disorders. These intermediate phenotypes identify both affected and unaffected members of an affected family, including offspring at risk, providing a more direct connection with underlying biological vulnerability. Our group has utilized heritable neurophysiological features (i.e., brain oscillations) as endophenotypes, making it possible to identify susceptibility genes that may be difficult to detect with diagnosis alone. We have discussed our findings of significant linkage and association between brain oscillations and genes in GABAergic, cholinergic and glutamatergic systems (GABRA2, CHRM2, and GRM8). We have also shown that some oscillatory indices from both resting and active cognitive states have revealed a common subset of genetic foci that are shared with the diagnosis of alcoholism and related disorders. Implications of our findings have been discussed in the context of physiological and pharmacological studies on receptor function. These findings underscore the utility of quantitative neurophysiological endophenotypes in the study of the genetics of brain function and the genetic diathesis underlying complex psychiatric disorders.
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Registered trials
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