ArticleNeuron glia biology2007
Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve.
Article in Neuron glia biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Millesi's Classification of Nerve Fibrosis Remains Underutilized in Modern Peripheral Nerve Research.Muscle & nerve · 2026Review
- Increased CD16a (FcγRIIIA) Expression in The Tumor Microenvironment of Atypical Neurofibromatous Neoplasms of Uncertain Biologic Potential May Be Associated with Progression from Neurofibromas to Atypical Neurofibromas.Journal of personalized medicine · 2023Article
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- AfterNeuro-oncology advances · 2020Review
- Sustained activation of ERK1/2 MAPK in Schwann cells causes corneal neurofibroma.Journal of neuroscience research · 2017Article
- Strength of ERK1/2 MAPK Activation Determines Its Effect on Myelin and Axonal Integrity in the Adult CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Novel Acellular Scaffold Made from Decellularized Schwann Cell Sheets for Peripheral Nerve Regeneration.Regenerative engineering and translational medicine · 2015Article
- Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.Pediatric blood & cancer · 2015Article
- In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain.Journal of neuroimmunology · 2015Article
- Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.Acta neuropathologica · 2013Article
- Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells.Molecular cancer therapeutics · 2011Article
- Back to the future: proceedings from the 2010 NF Conference.American journal of medical genetics. Part A · 2011Article
- Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cells.Current opinion in hematology · 2010Review
- Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Expression of the human epidermal growth factor receptor (EGFR) in murine Schwann cells results in loss of axon-Schwann cell interactions and collagen deposition, modeling peripheral nerve response to injury and tumorigenesis. Mast cells infiltrate nerves in all three situations. We show that mast cells are present in normal mouse peripheral nerve beginning at 4 weeks of age, and that the number of mast-cells in EGFR(+) nerves increases abruptly at 5-6 weeks of age as axons and Schwann cells dissociate. The increase in mast cell number is preceded and accompanied by elevated levels of mRNAs encoding the mast-cell chemoattractants Rantes, SCF and VEGF. Genetic ablation of mast cells and bone marrow reconstitution in W(41) x EGFR(+) mice indicate a role for mast cells in loss of axon-Schwann cell interactions and collagen deposition. Pharmacological stabilization of mast cells by disodium cromoglycate administration to EGFR(+) mice also diminished loss of axon-Schwann cell interaction. Together these three lines of evidence support the hypothesis that mast cells can contribute to alterations in peripheral nerves.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.