ArticleNeuron glia biology2007
Two distinct mechanisms segregate Prospero in the longitudinal glia underlying the timing of interactions with axons.
Article in Neuron glia biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Article
- Lineage-guided Notch-dependent gliogenesis byDevelopment (Cambridge, England) · 2018Article
- Go and stop signals for glial regeneration.Current opinion in neurobiology · 2017Review
- Multifunctional glial support by Semper cells in the Drosophila retina.PLoS genetics · 2017Article
- Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki.The Journal of cell biology · 2016Article
- Article
- The glial regenerative response to central nervous system injury is enabled by pros-notch and pros-NFκB feedback.PLoS biology · 2011Article
- Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Prospero is required in dividing longitudinal glia (LG) during axon guidance; initially to enable glial division in response to neuronal contact, and subsequently to maintain glial precursors in a quiescent state with mitotic potential. Only Prospero-positive LG respond to neuronal ablation by over-proliferating, mimicking a glial-repair response. Prospero is distributed unequally through the progeny cells of the longitudinal glioblast lineage. Just before axon contact the concentration of Prospero is higher in two of the four progeny cells, and after axon guidance Prospero is present only in six out of ten progeny LG. Here we ask how Prospero is distributed unequally in these two distinct phases. We show that before neuronal contact, longitudinal glioblasts undergo invaginating divisions, perpendicular to the ectodermal layer. Miranda is required to segregate Prospero asymmetrically up to the four glial-progeny stage. After neuronal contact, Prospero is present in only the LG that activate Notch signalling in response to Serrate provided by commissural axons, and Numb is restricted to the glia that do not contain Prospero. As a result of this dual regulation of Prospero deployment, glia are coupled to the formation and maintenance of axonal trajectories.
Identifiers
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Registered trials
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