ArticleGlycoconjugate journal2009
Survey of O-GlcNAc level variations in Xenopus laevis from oogenesis to early development.
Article in Glycoconjugate journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Protein O-GlcNAcylation in reproductive biology and the impact of metabolic disease.Human reproduction update · 2025Review
- O-GlcNAc participates in the meiosis of aging oocytes by mediating mitochondrial function.Reproduction (Cambridge, England) · 2024Article
- The differential role of Leydig cells in the skin and gills of Lissotriton italicus larvae.Microscopy research and technique · 2022Article
- NAT10 MaintainsFrontiers in endocrinology · 2022Article
- Role ofPhysiological reviews · 2021Review
- Article
- Polymorphism in the intron 20 of porcine O-linked N-acetylglucosamine transferase.Asian-Australasian journal of animal sciences · 2017Article
- The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport.Oxidative medicine and cellular longevity · 2017Review
- O-GlcNAcylation: a bridge between glucose and cell differentiation.Journal of cellular and molecular medicine · 2016Review
- Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum.The Journal of biological chemistry · 2015Article
- A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development.The Biochemical journal · 2015Article
- Two-way communication between the metabolic and cell cycle machineries: the molecular basis.Cell cycle (Georgetown, Tex.) · 2015Review
- O-GlcNAcylation: A New Cancer Hallmark?Frontiers in endocrinology · 2013Article
- Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition.The EMBO journal · 2010Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the impact of O-linked-N-acetylglucosaminylation (O-GlcNAc) in gametes production and developmental processes. Here we investigated changes in O-GlcNAc, UDP-GlcNAc and O-GlcNAc transferase (OGT) levels in Xenopus laevis from oogenesis to embryo hatching. We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools. Upon progesterone stimulation, an O-GlcNAc level burst occurred during meiotic resumption long before MPF and Mos-Erk2 pathways activations. Finally, we observed high levels of O-GlcNAc, UDP-GlcNAc and OGT during segmentation that decreased concomitantly at the onset of gastrulation. Nevertheless, no correlation between the glycosylation, the nucleotide-sugar and the glycosyltransferase was observed after neurulation. Our results show that O-GlcNAc is regulated throughout oogenesis and development within a complex pattern and suggest that dysfunctions in the dynamics of this glycosylation could lead to developmental abnormalities.
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Registered trials
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