SynthesisLangenbeck's archives of surgery2009
Probiotics in patients with severe acute pancreatitis: a meta-analysis.
Synthesis in Langenbeck's archives of surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee.Journal of pediatric gastroenterology and nutrition · 2018Guideline
- Use of probiotics in the treatment of severe acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials.Critical care (London, England) · 2014Pooled it
- Probiotics' effects on the incidence of nosocomial pneumonia in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2012Pooled it
- Evidence-based use of enteral nutrition in acute pancreatitis.Langenbeck's archives of surgery · 2010Pooled it
- Review
- Diagnosis and Treatment of Acute Pancreatitis.Diagnostics (Basel, Switzerland) · 2022Review
- Gut Dysbiosis in Pancreatic Diseases: A Causative Factor and a Novel Therapeutic Target.Frontiers in nutrition · 2022Review
- Nutrition and Acute Pancreatitis.Journal of clinical medicine · 2021Review
- Nutrition in Gastrointestinal Disease: Liver, Pancreatic, and Inflammatory Bowel Disease.Journal of clinical medicine · 2019Article
- Arguments for routine administration of probiotics for NEC prevention.Current opinion in pediatrics · 2019Review
- Supplemented Use of Pre-, Pro-, and Synbiotics in Severe Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis of 13 Randomized Controlled Trials.Frontiers in pharmacology · 2018Article
- Clinical practice guideline: management of acute pancreatitis.Canadian journal of surgery. Journal canadien de chirurgie · 2016Review
- Advances in Management of Acute Pancreatitis.Gastroenterology clinics of North America · 2016Review
- Recent Advances in Managing Acute Pancreatitis.F1000Research · 2015Review
- Contributions of intestinal bacteria to nutrition and metabolism in the critically ill.The Surgical clinics of North America · 2011Review
- New randomized trial of probiotics in pancreatitis needed? Caution advised.Langenbeck's archives of surgery · 2009Article
- Hypothermia-Related Acute Pancreatitis.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study focuses on probiotics in patients with severe acute pancreatitis. It assesses whether enteral feeding with probiotics use reduces infected necrosis and death in severe acute pancreatitis. MATERIALS AND
methodsWe searched the Cochrane Library, Medline, Embase, and Chinese Biomedicine Database. Quality assessment and data extraction were done by two reviewers independently. The statistical analysis was performed by RevMan4.2.10 software. The result was expressed with odds ratio (OR) for the categorical variable.
resultsFour studies were included. The result showed that using probiotics could not reduce the risk of infection pancreatic necrosis (OR = 0.56, 95% CI [0.13, 2.35]). There is no significant difference between the two groups in mortality (OR = 0.83, 95% CI [0.14, 4.83]), the mean duration of hospital (WMD = -1.20, 95% CI [-13.13, 10.92]) and the required operation (OR = 0.59, 95% CI [0.11, 3.07]).
conclusionThe present study showed the enteral feeding with probiotic could not reduce the infected necrosis and mortality. Future large-scale, high-quality, placebo-controlled, double-blind trials are needed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.