Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2008
Sclerosing injections to treat midportion Achilles tendinosis: a randomised controlled study evaluating two different concentrations of Polidocanol.
Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Injection therapies for Achilles tendinopathy.The Cochrane database of systematic reviews · 2015Pooled it
- No beneficial effect of Polidocanol treatment in Achilles tendinopathy: a randomised controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Trial
- The evolving landscape of minimally invasive procedures in musculoskeletal diseases-Part II.Frontiers in medicine · 2026Review
- The Role of Vascular Endothelial Growth Factor in Tendon Healing.Frontiers in physiology · 2021Review
- Sclerotherapy and prolotherapy for chronic patellar tendinopathies - a promising therapy with limited available evidence, a systematic review.Journal of experimental orthopaedics · 2020Review
- Chinese Consensus on Insertional Achilles Tendinopathy.Orthopaedic journal of sports medicine · 2019Article
- [Differential diagnosis of heel pain].Der Orthopade · 2019Article
- Effects of mesenchymal stromal cells versus serum on tendon healing in a controlled experimental trial in an equine model.BMC musculoskeletal disorders · 2018Article
- [Insertional Achilles tendinopathy : Differentiated diagnostics and therapy].Der Unfallchirurg · 2017Review
- Non-insertional Achilles tendinopathy.EFORT open reviews · 2016Review
- Achilles Tendinopathy: Current Concepts about the Basic Science and Clinical Treatments.BioMed research international · 2016Review
- Sclerosing injections and ultrasound-guided arthroscopic shaving for patellar tendinopathy: good clinical results and decreased tendon thickness after surgery-a medium-term follow-up study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
- Injection treatment for chronic midportion Achilles tendinopathy: do we need that many alternatives?Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2011Article
- Deciphering the pathogenesis of tendinopathy: a three-stages process.Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT · 2010Article
- Ultrasound-guided treatments for chronic Achilles tendinopathy: an update and current status.Skeletal radiology · 2010Review
- New options in the management of tendinopathy.Open access journal of sports medicine · 2010Review
- The prevalence of neovascularity in patients clinically diagnosed with rotator cuff tendinopathy.BMC musculoskeletal disorders · 2009Article
- Imaging of tendons.Sports health · 2009Article
- Does the dosage matter in sclerosing polidocanol injections in Achilles tendinopathy?Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2009Article
- Strain Ultrasound Elastography in the Achilles Tendon of Ankylosing Spondylitis Patients Treated With Anti-TNF-α: A Preliminary Study.In vivo (Athens, Greece)Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two to three ultrasound (US) and colour Doppler (CD)-guided injections of the sclerosing substance Polidocanol (5 mg/ml) have been demonstrated to give good clinical results in patients with chronic midportion Achilles tendinopathy. This study aimed to investigate if a higher concentration of Polidocanol (10 mg/ml) would lead to a less number of treatments, and lower volumes, needed for good clinical results. Fifty-two consecutive Achilles tendons (48 patients, mean age 49.6 years) with chronic painful midportion Achilles tendinopathy, were randomised to treatment with Polidocanol 5 mg/ml (group A) or 10 mg/ml (group B). The patients and treating physician were blinded to the concentration of Polidocanol injected. All patients had structural tendon changes and neovascularisation in the Achilles midportion. Treatment was US + CD-guided injections targeting the region with neovascularisation (outside ventral tendon). A maximum of three treatments (6-8 weeks in between) were given before evaluation. Patients not satisfied after three treatments were given additional treatment with Polidocanol 10 mg/ml, up to five treatments. For evaluation, the patients recorded the severity of Achilles tendon pain during activity on a visual analogue scale (VAS), before and after treatment. Patient satisfaction with treatment was also assessed. At follow-up (mean 14 months) after three treatments, 18/26 patients in group A and 19/26 patients in group B were satisfied with the treatment and had a significantly reduced level of tendon pain (P < 0.05). After completion of the study, additional treatments with Polidocanol 10 mg/ml in the not satisfied patients resulted in 26/26 satisfied patients in both groups A and B. In summary, we found no significant differences in the number of satisfied patients, number of injections or volumes given, between patients treated with 5 or 10 mg/ml Polidocanol.
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