ArticleDiabetes2008
G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes.
Article in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The Role ofGenes · 2026Pooled it
- The Role ofGenes · 2025Pooled it
- Meta-analysis of diabetic nephropathy associated genetic variants in inflammation and angiogenesis involved in different biochemical pathways.BMC medical genetics · 2014Pooled it
- Bioinformatics and Next-Generation Data Analysis for Identification of Genes and Molecular Pathways Involved in Subjects with Diabetes and Obesity.Medicina (Kaunas, Lithuania) · 2023Article
- Role of the UNC13 family in human diseases: A literature review.AIMS neuroscience · 2023Review
- Genetic and epigenetic background of diabetic kidney disease.Frontiers in endocrinology · 2023Review
- The Association of UNC13B Gene Polymorphisms and Diabetic Kidney Disease in a Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients.International journal of chronic diseases · 2019Article
- Epigenetics in diabetic nephropathy, immunity and metabolism.Diabetologia · 2018Review
- High glucose-induced cytoplasmic translocation of Dnmt3a contributes to CTGF hypo-methylation in mesangial cells.Bioscience reports · 2016Article
- Genetics and Epigenetics of Diabetic Nephropathy.Kidney diseases (Basel, Switzerland) · 2015Review
- The genetics of diabetic complications.Nature reviews. Nephrology · 2015Review
- Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications.Journal of diabetes research · 2015Review
- Genetics of diabetes complications.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- A powerful statistical method identifies novel loci associated with diastolic blood pressure triggered by nonlinear gene-environment interaction.BMC proceedings · 2014Article
- Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians.Molecular genetics and metabolism · 2011Article
- Article
- Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus.BMC medical genomics · 2010Article
- Article
- Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus.Diabetologia · 2009Article
Corrections and comments
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Authors and funding
26 authors at 13 institutions in 5 countries.
Funding
Abstract
objectiveGenetic and environmental factors modulate the susceptibility to diabetic nephropathy, as initiating and/or progression factors. The objective of the European Rational Approach for the Genetics of Diabetic Complications (EURAGEDIC) study is to identify nephropathy susceptibility genes. We report molecular genetic studies for 127 candidate genes for nephropathy. RESEARCH DESIGN AND
methodsPolymorphisms were identified through sequencing of promoter, exon, and flanking intron gene regions and a database search. A total of 344 nonredundant SNPs and nonsynonymous variants were tested for association with diabetic nephropathy (persistent albuminuria >/=300 mg/24 h) in a large type 1 diabetes case/control (1,176/1,323) study from three European populations.
resultsOnly one SNP, rs2281999, located in the UNC13B gene, was significantly associated with nephropathy after correction for multiple testing. Analyses of 21 additional markers fully characterizing the haplotypic variability of the UNC13B gene showed consistent association of SNP rs13293564 (G/T) located in intron 1 of the gene with nephropathy in the three populations. The odds ratio (OR) for nephropathy associated with the TT genotype was 1.68 (95% CI 1.29-2.19) (P = 1.0 x 10(-4)). This association was replicated in an independent population of 412 case subjects and 614 control subjects (combined OR of 1.63 [95% CI 1.30-2.05], P = 2.3 x 10(-5)).
conclusionsWe identified a polymorphism in the UNC13B gene associated with nephropathy. UNC13B mediates apopotosis in glomerular cells in the presence of hyperglycemia, an event occurring early in the development of nephropathy. We propose that this polymorphism could be a marker for the initiation of nephropathy. However, further studies are needed to clarify the role of UNC13B in nephropathy.
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