ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Beyond STMN1: stathmin-family control of microtubule dynamics and paclitaxel resistance in cancer.Frontiers in oncology · 2026Review
- RREB1 regulates neuronal proteostasis and the microtubule network.Science advances · 2024Article
- HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration.eLife · 2021Article
- Foxp1 regulation of neonatal vocalizations via cortical development.Genes & development · 2017Article
- The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.Molecular biology of the cell · 2015Article
- Overexpression of SCLIP promotes growth and motility in glioblastoma cells.Cancer biology & therapy · 2015Article
- Neuronal phenotype dependency of agonist-induced internalization of the 5-HT(1A) serotonin receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease.The Journal of cell biology · 2012Article
- Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development.Development (Cambridge, England) · 2012Article
- Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons.The Journal of biological chemistry · 2012Article
- Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal weeks: a metamorphosis?Frontiers in neuroanatomy · 2012Article
- Purkinje cell maturation participates in the control of oligodendrocyte differentiation: role of sonic hedgehog and vitronectin.PloS one · 2012Article
- Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases.Molecular biology of the cell · 2011Article
- Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling.Neuron · 2010Article
- Induction of early Purkinje cell dendritic differentiation by thyroid hormone requires RORα.Neural development · 2010Article
- Drosophila stathmins bind tubulin heterodimers with high and variable stoichiometries.The Journal of biological chemistry · 2010Article
- Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development.The Journal of biological chemistry · 2010Article
- Dendrite formation of cerebellar Purkinje cells.Neurochemical research · 2009Review
- Article
- The roles of STMN3 in various cancers.Science progressReview
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebellar Purkinje cells elaborate one of the most complex dendritic arbors among neurons to integrate the numerous signals they receive from the cerebellum circuitry. Their dendritic differentiation undergoes successive, tightly regulated phases of development involving both regressive and growth events. Although many players regulating the late phases of Purkinje cell dendritogenesis have been identified, intracellular factors controlling earlier phases of dendritic development remain mostly unknown. In this study, we explored the biological properties and functions of SCLIP, a protein of the stathmin family, in Purkinje cell dendritic differentiation and cerebellum development. Unlike the other stathmins, SCLIP is strongly expressed in Purkinje cells during cerebellar development and accumulates in their dendritic processes at a critical period of their formation and outgrowth. To reveal SCLIP functions, we developed a lentiviral-mediated approach on cerebellar organotypic cultures to inhibit or increase its expression in Purkinje cells in their tissue environment. Depletion of SCLIP promoted retraction of the Purkinje cell primitive process and then prevented the formation of new dendrites at early stages of postnatal development. It also prevented their elongation and branching at later phases of differentiation. Conversely, SCLIP overexpression promoted dendritic branching and development. Together, our results demonstrate for the first time that SCLIP is crucial for both the formation and proper development of Purkinje cell dendritic arbors. SCLIP appears thus as a novel and specific factor that controls the early phases of Purkinje cell dendritic differentiation during cerebellum development.
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