ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Functional topography and integration of the contralateral and ipsilateral retinocollicular projections of ephrin-A-/- mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024Review
- Magnetic Stimulation as a Therapeutic Approach for Brain Modulation and Repair: Underlying Molecular and Cellular Mechanisms.International journal of molecular sciences · 2023Review
- Interactions between Guidance Cues and Neuronal Activity: Therapeutic Insights from Mouse Models.International journal of molecular sciences · 2023Review
- Diverse modes of binocular interactions in the mouse superior colliculus.Journal of neurophysiology · 2022Article
- Manipulating the Level of Sensorimotor Stimulation during LI-rTMS Can Improve Visual Circuit Reorganisation in Adult Ephrin-A2A5International journal of molecular sciences · 2022Article
- A little goes a long way: Neurobiological effects of low intensity rTMS and implications for mechanisms of rTMS.Current research in neurobiology · 2022Review
- Moving back in the brain to drive the field forward: Targeting neurostimulation to different brain regions in animal models of depression and neurodegeneration.Journal of neuroscience methods · 2021Article
- Molecular, Cellular and Functional Changes in the Retinas of Young Adult Mice Lacking the Voltage-Gated KInternational journal of molecular sciences · 2021Article
- Article
- Low-intensity repetitive transcranial magnetic stimulation requires concurrent visual system activity to modulate visual evoked potentials in adult mice.Scientific reports · 2018Article
- Downstream mediators of Ten-m3 signalling in the developing visual pathway.BMC neuroscience · 2017Article
- Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus.Molecular brain · 2016Article
- Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons.Neural development · 2015Article
- Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush.Cell death & disease · 2015Article
- Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders.Behavioural brain research · 2015Article
- Low-intensity repetitive transcranial magnetic stimulation improves abnormal visual cortical circuit topography and upregulates BDNF in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Different roles of axon guidance cues and patterned spontaneous activity in establishing receptive fields in the mouse superior colliculus.Frontiers in neural circuits · 2014Article
- Standard anatomical and visual space for the mouse retina: computational reconstruction and transformation of flattened retinae with the Retistruct package.PLoS computational biology · 2013Article
- On the Importance of Countergradients for the Development of Retinotopy: Insights from a Generalised Gierer Model.PloS one · 2013Article
- Restricted perinatal retinal degeneration induces retina reshaping and correlated structural rearrangement of the retinotopic map.Nature communications · 2013Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topographically ordered projections are established by molecular guidance cues and refined by neuronal activity. Retinal input to a primary visual center, the superior colliculus (SC), is bilateral with a dense contralateral projection and a sparse ipsilateral one. Both projections are topographically organized, but in opposing anterior-posterior orientations. This arrangement provides functionally coherent input to each colliculus from the binocular visual field, supporting visual function. When guidance cues involved in contralateral topography (ephrin-As) are absent, crossed retinal ganglion cell (RGC) axons form inappropriate terminations within the SC. However, the organization of the ipsilateral projection relative to the abnormal contralateral input remains unknown, as does the functional capacity of both projections. We show here that in ephrin-A(-/-) mice, the SC contains an expanded, diffuse ipsilateral projection. Electrophysiological recording demonstrated that topography of visually evoked responses recorded from the contralateral superior colliculus of ephrin-A(-/-) mice displayed similar functional disorder in all genotypes, contrasting with their different degrees of anatomical disorder. In contrast, ipsilateral responses were retinotopic in ephrin-A2(-/-) but disorganized in ephrin-A2/A5(-/-) mice. The lack of integration of binocular input resulted in specific visual deficits, which could be reversed by occlusion of one eye. The discrepancy between anatomical and functional topography in both the ipsilateral and contralateral projections implies suppression of inappropriately located terminals. Moreover, the misalignment of ipsilateral and contralateral visual information in ephrin-A2/A5(-/-) mice suggests a role for ephrin-As in integrating convergent visual inputs.
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