ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 92 citations in OpenAlex.
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- A recurrent neural circuit in Drosophila temporally sharpens visual inputs.Current biology : CB · 2025Article
- A recurrent neural circuit inbioRxiv : the preprint server for biology · 2024Article
- A Closer Look at Histamine inInternational journal of molecular sciences · 2024Review
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- Light exposure during development affects physiology of adults inFrontiers in physiology · 2022Article
- Synaptic targets of photoreceptors specialized to detect color and skylight polarization ineLife · 2021Article
- Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance.PLoS neglected tropical diseases · 2021Article
- Parallel Synaptic Acetylcholine Signals Facilitate Large Monopolar Cell Repolarization and Modulate Visual Behavior inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Mechanisms underlying homeostatic plasticity in theProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Color vision in insects: insights from Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Article
- Communication Among Photoreceptors and the Central Clock Affects Sleep Profile.Frontiers in physiology · 2020Article
- Better Sleep at Night: How Light Influences Sleep inFrontiers in physiology · 2020Review
- The HisCl1 histamine receptor acts in photoreceptors to synchronize Drosophila behavioral rhythms with light-dark cycles.Nature communications · 2019Article
- Location and functions of Inebriated in theBiology open · 2018Article
- Multifunctional glial support by Semper cells in the Drosophila retina.PLoS genetics · 2017Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Histamine (HA) is the photoreceptor neurotransmitter in arthropods, directly gating chloride channels on large monopolar cells (LMCs), postsynaptic to photoreceptors in the lamina. Two histamine-gated channel genes that could contribute to this channel in Drosophila are hclA (also known as ort) and hclB (also known as hisCl1), both encoding novel members of the Cys-loop receptor superfamily. Drosophila S2 cells transfected with these genes expressed both homomeric and heteromeric histamine-gated chloride channels. The electrophysiological properties of these channels were compared with those from isolated Drosophila LMCs. HCLA homomers had nearly identical HA sensitivity to the native receptors (EC(50) = 25 microM). Single-channel analysis revealed further close similarity in terms of single-channel kinetics and subconductance states ( approximately 25, 40, and 60 pS, the latter strongly voltage dependent). In contrast, HCLB homomers and heteromeric receptors were more sensitive to HA (EC(50) = 14 and 1.2 microM, respectively), with much smaller single-channel conductances ( approximately 4 pS). Null mutations of hclA (ort(US6096)) abolished the synaptic transients in the electroretinograms (ERGs). Surprisingly, the ERG "on" transients in hclB mutants transients were approximately twofold enhanced, whereas intracellular recordings from their LMCs revealed altered responses with slower kinetics. However, HCLB expression within the lamina, assessed by both a GFP (green fluorescent protein) reporter gene strategy and mRNA tagging, was exclusively localized to the glia cells, whereas HCLA expression was confirmed in the LMCs. Our results suggest that the native receptor at the LMC synapse is an HCLA homomer, whereas HCLB signaling via the lamina glia plays a previously unrecognized role in shaping the LMC postsynaptic response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.