ArticleClinical and vaccine immunology : CVI2008
Levels of soluble CD163 and severity of malaria in children in Ghana.
Article in Clinical and vaccine immunology : CVI, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
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- M1 macrophage features in severe Plasmodium falciparum malaria patients with pulmonary oedema.Malaria journal · 2020Article
- Mononuclear Phagocyte Activation Is Associated With the Immunopathology of Psoriasis.Frontiers in immunology · 2020Article
- The blood transcriptome of childhood malaria.EBioMedicine · 2019Article
- Clinical significance of sCD163 and its possible role in asthma (Review).Molecular medicine reports · 2017Review
- Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease.Arthritis research & therapy · 2017Article
- Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity.Scientific reports · 2016Article
- Plasma levels of eight different mediators and their potential as biomarkers of various clinical malaria conditions in African children.Malaria journal · 2016Article
- A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children.Genetics & epigenetics · 2016Article
- Macrophage Activation Syndrome-Associated Markers in Severe Dengue.International journal of medical sciences · 2016Article
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- Severity of malaria in relation to a complement receptor 1 polymorphism: a case-control study.Pathogens and global health · 2015Article
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- Haptoglobin phenotype prevalence and cytokine profiles during Plasmodium falciparum infection in Dogon and Fulani ethnic groups living in Mali.Malaria journal · 2013Article
- CD163 and inflammation: biological, diagnostic, and therapeutic aspects.Antioxidants & redox signaling · 2013Review
- Soluble CD163, a product of monocyte/macrophage activation, is inversely associated with haemoglobin levels in placental malaria.PloS one · 2013Article
- Prolonged neutrophil dysfunction after Plasmodium falciparum malaria is related to hemolysis and heme oxygenase-1 induction.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria.Infection and immunity · 2012Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD163 is an acute-phase-regulated monocyte/macrophage membrane receptor expressed late in inflammation. It is involved in the haptoglobin-mediated removal of free hemoglobin from plasma, has been identified as a naturally soluble plasma glycoprotein with potential anti-inflammatory properties, and is possibly linked to an individual's haptoglobin phenotype. High levels of soluble CD163 (sCD163) in a malaria episode may therefore downregulate inflammation and curb disease severity. In order to verify this, the relationships between sCD163 levels, malaria severity, and selected inflammatory mediators (tumor necrosis factor alpha [TNF-alpha], interleukin-6 [IL-6], and IL-10) were assessed by enzyme-linked immunosorbent assay using plasma samples obtained from pediatric malaria patients with uncomplicated malaria (UM [n = 38]), cerebral malaria (CM [n = 52]), and severe malarial anemia (SA [n = 55]) during two consecutive malaria transmission seasons (2002 and 2003). Median sCD163 levels were higher in UM (11.9 microg/ml) patients than in SA (7.7 microg/ml; P = 0.010) and CM (8.0 microg/ml; P = 0.031) patients. Levels of sCD163 were also higher in all patient groups than in a group of 81 age-matched healthy controls. The higher sCD163/TNF-alpha ratio in UM patients, coupled with the fact that sCD163 levels correlated with TNF-alpha levels in UM patients but not in CM and SA patients, suggests inflammatory dysregulation in the complicated cases. The study showed that sCD163 levels are elevated during acute malaria. High sCD163 levels in UM patients may be due to the induction of higher-level anti-inflammatory responses, enabling them to avoid disease complications. It is also possible that UM patients simply lost their CD163 receptors from macrophages in inflammatory sites while complicated-malaria patients still had their receptors attached to activated macrophages, reflecting ongoing and higher-level inflammation associated with complicated malaria.
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