ArticleJournal of molecular endocrinology2008
Comparative effects of estradiol, methyl-piperidino-pyrazole, raloxifene, and ICI 182 780 on gene expression in the murine uterus.
Article in Journal of molecular endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Identification of Potentially Novel Molecular Targets of Endometrial Cancer Using a Non-Biased Proteomic Approach.Cancers · 2023Article
- Icariin Alleviates Wear Particle-Induced Periprosthetic OsteolysisFrontiers in pharmacology · 2021Article
- Estradiol treatment attenuates high fat diet-induced microgliosis in ovariectomized rats.Hormones and behavior · 2020Article
- Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of theCell & bioscience · 2019Article
- Selective activation of estrogen receptors, ERα and GPER-1, rapidly decreases food intake in female rats.Hormones and behavior · 2018Article
- Article
- The Effects of Estrogen Receptors' Antagonist on Brain Edema, Intracranial Pressure and Neurological Outcomes after Traumatic Brain Injury in Rat.Iranian biomedical journal · 2015Article
- Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling.British journal of pharmacology · 2013Article
- The role of S6K1 in ER-positive breast cancer.Cell cycle (Georgetown, Tex.) · 2012Article
- The ovarian hormone estradiol plays a crucial role in the control of food intake in females.Physiology & behavior · 2011Review
- The conundrum of estrogen receptor oscillatory activity in the search for an appropriate hormone replacement therapy.Endocrinology · 2011Article
- Activation of ERα is necessary for estradiol's anorexigenic effect in female rats.Hormones and behavior · 2010Article
- Contrasting effects of different maternal diets on sexually dimorphic gene expression in the murine placenta.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Effect of a putative ERalpha antagonist, MPP, on food intake in cycling and ovariectomized rats.Physiology & behavior · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Selective estrogen receptor modulators (SERMs) are potentially useful in treating various endometrial disorders, including endometrial cancer, as they block some of the detrimental effects of estrogen. It remains unclear whether each SERM regulates a unique subset of genes and, if so, whether the combination of a SERM and 17beta-estradiol has an additive or synergistic effect on gene expression. We performed microarray analysis with Affymetrix Mouse Genome 430 2.0 short oligomer arrays to determine gene expression changes in uteri of ovariectomized mice treated with estradiol (low and high dose), methyl-piperidino-pyrazole (MPP), ICI 182 780, raloxifene, and combinations of high dose of estradiol with one of the SERM and dimethyl sulfoxide (DMSO) vehicle control. The nine treatments clustered into two groups, with MPP, raloxifene, and high dose of estradiol in one, and low dose of estradiol, ICI + estradiol, ICI, MPP + estradiol, and raloxifene + estradiol in the second group. Surprisingly, combining a high dose of estradiol with a SERM markedly increased (P<0.02) the number of regulated genes compared with each individual treatment. Analysis of expression for selected genes in uteri of estradiol and SERM-treated mice by quantitative (Q)RT-PCR generally supported the microarray results. For some cancer-associated genes, including Klk1, Ihh, Cdc45l, and Cdca8, administration of MPP or raloxifene with estradiol resulted in greater expression than estradiol alone (P<0.05). By contrast, ICI 182 780 suppressed more genes governing DNA replication compared with MPP and raloxifene treatments. Therefore, ICI 182 780 might be superior to MPP and raloxifene to treat estrogen-induced endometrial cancer in women.
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