ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2008
Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigation.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Changes in Cytokines Concentration Following Long-Distance Running: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2022Pooled it
- Protein phosphatase 2A impairs cardiac uptake of glucose in the mammalian heart.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Advances and Perspectives in Curcumin Regulation of Systemic Metabolism: A Focus on Multi-Organ Mechanisms.Antioxidants (Basel, Switzerland) · 2026Review
- Dynamic evolution and mechanism of myocardial glucose metabolism in different functional phenotypes of diabetic cardiomyopathy - a study based onDiabetology & metabolic syndrome · 2023Article
- Myocardial salvage by succinate dehydrogenase inhibition in ischemia-reperfusion injury depends on diabetes stage in rats.Molecular and cellular biochemistry · 2021Article
- Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy.Circulation research · 2020Review
- Clinical significance of quantitative assessment of glucose utilization in patients with ischemic cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Impact of curcumin treatment on diabetic albino rats.Saudi journal of biological sciences · 2020Article
- Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress.American journal of physiology. Heart and circulatory physiology · 2019Article
- Non-invasive determination of blood input function to compute rate of myocardial glucose uptake from dynamic FDG PET images of rat heart in vivo: comparative study between the inferior vena cava and the left ventricular blood pool with spill over and partial volume corrections.Physics in medicine and biology · 2019Article
- Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture.Frontiers in physiology · 2019Review
- The association between diabetes mellitus and reduction in myocardial glucose uptake: a population-basedBMC cardiovascular disorders · 2018Article
- Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking.Cardiovascular diabetology · 2018Article
- Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by UsingContrast media & molecular imaging · 2018Article
- Effects of hypoglycemia on myocardial susceptibility to ischemia-reperfusion injury and preconditioning in hearts from rats with and without type 2 diabetes.Cardiovascular diabetology · 2017Article
- Longitudinal evaluation of myocardial glucose metabolism and contractile function in obese type 2 diabetic db/db mice using small-animal dynamicOncotarget · 2017Article
- Sexual dimorphism in myocardial acylcarnitine and triglyceride metabolism.Biology of sex differences · 2016Article
- Determination of Fatty Acid Metabolism with Dynamic [11C]Palmitate Positron Emission Tomography of Mouse Heart In Vivo.Molecular imaging · 2015Article
- Transcript levels of class I GLUTs within individual tissues and the direct relationship between GLUT1 expression and glucose metabolism in Atlantic cod (Gadus morhua).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- In vivo multi-tissue efficacy of peroxisome proliferator-activated receptor-γ therapy on glucose and fatty acid metabolism in obese type 2 diabetic rats.Obesity (Silver Spring, Md.) · 2013Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledDiabetic cardiomyopathy is associated with abnormalities in glucose metabolism. We evaluated myocardial glucose metabolism in a rodent model of type 2 diabetes, namely the Zucker diabetic fatty (ZDF) rat, and validated PET measurements of glucose uptake against gene and protein expression of glucose transporters (GLUTs).
methodsSix lean and ZDF rats underwent small-animal PET at the age of 14 wk and at the age of 19 wk. The imaging protocol consisted of a 60-min dynamic acquisition with 18F-FDG (18.5-29.6 MBq). Dynamic images were reconstructed using filtered backprojection with a 2.5 zoom on the heart and 40 frames per imaging session. PET measurements of myocardial glucose uptake (MGUp) rate and utilization were determined with an input function derived by the hybrid image-blood-sampling algorithm on recovery-corrected anterolateral myocardial regions of interest. After the PET session at week 19 (W19), hearts were extracted for gene and protein expression analysis of GLUT-1 and GLUT-4. The dependence of MGUp on gene expression of GLUT-1 and GLUT-4 was characterized by multiple-regression analysis.
resultsMGUp in ZDF rats at both week 14 (W14) and W19 (P < 0.006) was significantly lower than MGUp in lean littermate control rats. Moreover, lean rats at W19 displayed significantly higher MGUp than they did at W14 (P = 0.007). Consistent with a diminished MGUp result, gene expression of GLUT-4 was significantly (P = 0.004) lower in ZDF rats. Finally, MGUp significantly (P = 0.0003) correlated with gene expression of GLUT-4.
conclusionUsing small-animal PET, we confirmed alterations in myocardial glucose utilization and validated PET measurement of MGUp against gene and protein expression of GLUTs in the diabetic heart of an animal model of type 2 diabetes.
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