ReviewProceedings of the National Academy of Sciences of the United States of America2008
How vision begins: an odyssey.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
106 citing papers in PubMed, 181 citations in OpenAlex.
- Revisiting retinal and macular degeneration in the genomics era.Nature reviews. Genetics · 2026Review
- Discovery and design of photocyclic animal opsins: potential application to gene therapy from non-visual opsin research.Eye and vision (London, England) · 2025Review
- Retinoid dynamics in vision: from visual cycle biology to retina disease treatments.Pharmacology & therapeutics · 2025Review
- cAMP-Mediated Modulation of Functions of Green- and Blue-Sensitive Cones in Zebrafish.International journal of molecular sciences · 2025Article
- The molecular mechanisms of visual chromophore release from cellular retinaldehyde-binding protein.Structure (London, England : 1993) · 2025Article
- Stargardt's Disease: Molecular Pathogenesis and Current Therapeutic Landscape.International journal of molecular sciences · 2025Review
- Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dark continuous noise from visual pigment as a major mechanism underlying rod-cone difference in light sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Allosteric Communication of the Dimerization and the Catalytic Domain in Photoreceptor Guanylate Cyclase.Biochemistry · 2024Article
- Circadian-independent light regulation of mammalian metabolism.Nature metabolism · 2024Review
- Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.Nature communications · 2023Article
- Ultrafast Transient Absorption Spectra and Kinetics of Rod and Cone Visual Pigments.Molecules (Basel, Switzerland) · 2023Review
- Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling.Protein & cell · 2023Article
- Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.The Journal of biological chemistry · 2023Article
- Structural view of G protein-coupled receptor signaling in the retinal rod outer segment.Trends in biochemical sciences · 2023Review
- The many faces of SIRT6 in the retina and retinal pigment epithelium.Frontiers in cell and developmental biology · 2023Review
- Acyl-CoA:wax alcohol acyltransferase 2 modulates the cone visual cycle in mouse retina.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- IMPDH dysregulation in disease: a mini review.Biochemical Society transactions · 2022Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Retinal rods and cones, which are the front-end light detectors in the eye, achieve wonders together by being able to signal single-photon absorption and yet also able to adjust their function to brightness changes spanning 10(9)-fold. How these cells detect light is now quite well understood. Not surprising for almost any biological process, the intial step of seeing reveals a rich complexity as the probing goes deeper. The odyssey continues, but the knowledge gained so far is already nothing short of remarkable in qualitative and quantitative detail. It has also indirectly opened up the mystery of odorant sensing. Basic science aside, clinical ophthalmology has benefited tremendously from this endeavor as well. This article begins by recapitulating the key developments in this understanding from the mid-1960s to the late 1980s, during which period the advances were particularly rapid and fit for an intricate detective story. It then highlights some details discovered more recently, followed by a comparison between rods and cones.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.