ArticleBMC plant biology2008
Correlation between amino acid residues converted by RNA editing and functional residues in protein three-dimensional structures in plant organelles.
Article in BMC plant biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 57 citations in OpenAlex.
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- Comparative organelle genomics in Daphniphyllaceae reveal phylogenetic position and organelle structure evolution.BMC genomics · 2025Article
- Massive RNA Editing in Ascetosporean Mitochondria.Microbes and environments · 2025Article
- The organelle genomes of the endangered seagrassFrontiers in plant science · 2025Article
- Organelle genomes reveal adaptive evolution and phylogenetic position of the endangeredFrontiers in plant science · 2025Article
- Seeing the unseen in characterizing RNA editome during rice endosperm development.Communications biology · 2024Article
- Assembly and characterization of the complete mitochondrial genome of Ventilago leiocarpa.Plant cell reports · 2024Article
- Hydrophobicity-Driven Increases in Editing in Mitochondrial mRNAs during the Evolution of Kinetoplastids.Molecular biology and evolution · 2023Article
- A Comprehensive Evolutionary Study of Chloroplast RNA Editing in Gymnosperms: A Novel Type of G-to-A RNA Editing Is Common in Gymnosperms.International journal of molecular sciences · 2022Article
- Comparative chloroplast genome and transcriptome analysis on the ancient genusFrontiers in plant science · 2022Article
- Homologous Cloning of Potassium Channel Genes From the Superior Apple Rootstock Line 12-2, Which is Tolerant to Apple Replant Disease.Frontiers in genetics · 2022Article
- The complete plastid genome sequence of the enigmatic moss, Takakia lepidozioides (Takakiopsida, Bryophyta): evolutionary perspectives on the largest collection of genes in mosses and the intensive RNA editing.Plant molecular biology · 2021Article
- A study of RNA-editing inForestry research · 2021Article
- Comparative Analysis of Complete Chloroplast Genome Sequences of Wild and CultivatedPlants (Basel, Switzerland) · 2020Article
- Detection and Analysis of C-to-U RNA Editing in Rice Mitochondria-Encoded ORFs.Plants (Basel, Switzerland) · 2020Article
- Comparative analysis of chloroplast genomes in Vasconcellea pubescens A.DC. and Carica papaya L.Scientific reports · 2020Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn plant organelles, specific messenger RNAs (mRNAs) are subjected to conversion editing, a process that often converts the first or second nucleotide of a codon and hence the encoded amino acid. No systematic patterns in converted sites were found on mRNAs, and the converted sites rarely encoded residues located at the active sites of proteins. The role and origin of RNA editing in plant organelles remain to be elucidated.
resultsHere we study the relationship between amino acid residues encoded by edited codons and the structural characteristics of these residues within proteins, e.g., in protein-protein interfaces, elements of secondary structure, or protein structural cores. We find that the residues encoded by edited codons are significantly biased toward involvement in helices and protein structural cores. RNA editing can convert codons for hydrophilic to hydrophobic amino acids. Hence, only the edited form of an mRNA can be translated into a polypeptide with helix-preferring and core-forming residues at the appropriate positions, which is often required for a protein to form a functional three-dimensional (3D) structure.
conclusionWe have performed a novel analysis of the location of residues affected by RNA editing in proteins in plant organelles. This study documents that RNA editing sites are often found in positions important for 3D structure formation. Without RNA editing, protein folding will not occur properly, thus affecting gene expression. We suggest that RNA editing may have conferring evolutionary advantage by acting as a mechanism to reduce susceptibility to DNA damage by allowing the increase in GC content in DNA while maintaining RNA codons essential to encode residues required for protein folding and activity.
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