ArticleEnvironmental microbiology2008
The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum).
Article in Environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.
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Who cites it
138 citing papers in PubMed, 265 citations in OpenAlex.
- Methanol Metabolism in the Cytochrome and Menaquinone-Containing Acetogen Moorella thermoacetica.Environmental microbiology · 2026Article
- Genomic and Transcriptomic Insights Into the Autotrophic Metabolism on HEnvironmental microbiology · 2026Article
- A hot origin of dissimilatory sulfite reduction catalyzed by DsrAB in the Paleoarchean Era.mLife · 2026Article
- Methanol and Carbon Monoxide Metabolism of the Thermophile Moorella caeni.Environmental microbiology · 2025Article
- Impact of acetate on COISME communications · 2025Article
- Molecular evolution of the Wood-Ljungdahl pathway and the reductive glycine pathway inFrontiers in microbiology · 2025Article
- Possibilities for Methanogenic and Acetogenic Life in Molecular Clouds.Life (Basel, Switzerland) · 2024Article
- Isolation and characterization of novel acetogenic Moorella strains for employment as potential thermophilic biocatalysts.FEMS microbiology ecology · 2024Article
- A Novel View on the Taxonomy of Sulfate-Reducing Bacterium 'Microorganisms · 2024Article
- Probing efficient microbial COMicrobial biotechnology · 2024Article
- Isopropanol production via the thermophilic bioconversion of sugars and syngas using metabolically engineered Moorella thermoacetica.Biotechnology for biofuels and bioproducts · 2024Article
- Engineered acetogenic bacteria as microbial cell factory for diversified biochemicals.Frontiers in bioengineering and biotechnology · 2024Review
- Hydrogenotrophic methanogenesis is the key process in the obligately syntrophic consortium of the anaerobic ameba Pelomyxa schiedti.The ISME journal · 2023Article
- Thermophilic Moorella thermoacetica as a platform microorganism for C1 gas utilization: physiology, engineering, and applications.Bioresources and bioprocessing · 2023Review
- A comparative genome analysis of theMicrobial genomics · 2023Article
- Acetate Production from Syngas Produced from Lignocellulosic Biomass Materials along with Gaseous Fermentation of the Syngas: A Review.Microorganisms · 2023Review
- Trait-Based Method of Quantitative Assessment of Ecological Functional Groups in the Human Intestinal Microbiome.Biology · 2023Article
- Microbial COArchives of microbiology · 2022Review
- Insights into the Structure and Protein Composition ofInternational journal of molecular sciences · 2022Article
- Reversible Hydrogenase Activity Confers Flexibility to Balance Intracellular Redox inFrontiers in microbiology · 2022Article
78 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
This paper describes the genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum), which is the model acetogenic bacterium that has been widely used for elucidating the Wood-Ljungdahl pathway of CO and CO(2) fixation. This pathway, which is also known as the reductive acetyl-CoA pathway, allows acetogenic (often called homoacetogenic) bacteria to convert glucose stoichiometrically into 3 mol of acetate and to grow autotrophically using H(2) and CO as electron donors and CO(2) as an electron acceptor. Methanogenic archaea use this pathway in reverse to grow by converting acetate into methane and CO(2). Acetogenic bacteria also couple the Wood-Ljungdahl pathway to a variety of other pathways to allow the metabolism of a wide variety of carbon sources and electron donors (sugars, carboxylic acids, alcohols and aromatic compounds) and electron acceptors (CO(2), nitrate, nitrite, thiosulfate, dimethylsulfoxide and aromatic carboxyl groups). The genome consists of a single circular 2 628 784 bp chromosome encoding 2615 open reading frames (ORFs), which includes 2523 predicted protein-encoding genes. Of these, 1834 genes (70.13%) have been assigned tentative functions, 665 (25.43%) matched genes of unknown function, and the remaining 24 (0.92%) had no database match. A total of 2384 (91.17%) of the ORFs in the M. thermoacetica genome can be grouped in orthologue clusters. This first genome sequence of an acetogenic bacterium provides important information related to how acetogens engage their extreme metabolic diversity by switching among different carbon substrates and electron donors/acceptors and how they conserve energy by anaerobic respiration. Our genome analysis indicates that the key genetic trait for homoacetogenesis is the core acs gene cluster of the Wood-Ljungdahl pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.