ArticleDigestive diseases and sciences2009
Clinical characteristics of patients with hepatitis C virus-related chronic liver disease seropositive for anticentromere antibody.
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Useful biomarkers for assessment of hepatitis C virus infection-associated autoimmune disorders.World journal of gastroenterology · 2014Review
- Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis.Auto- immunity highlights · 2013Review
- Clinical relevance of antibodies to cardiolipin in patients with chronic hepatitis C.Journal of clinical laboratory analysis · 2012Article
- Clinical significance of autoantibodies to p53 protein in patients with autoimmune liver diseases.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012Article
- Extrahepatic manifestations and autoantibodies in patients with hepatitis C virus infection.Clinical & developmental immunology · 2012Review
- Autoantibodies as prognostic markers in autoimmune liver disease.Digestive diseases and sciences · 2010Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between anticentromere antibody (ACA) and hepatitis C virus (HCV) infection remains unclear. We subjected eight patients with HCV-related chronic liver disease (CLD) seropositive for ACA to a battery of clinical and laboratory tests. The patient cohort was dominated by females, and four of the eight (50%) patients had a concomitant autoimmune disease. All of the patients had high titers of ACA (>or=1:320). The histological activity index scores in chronic hepatitis C (CH-C) patients with ACA were significantly higher than those in CH-C patients without antinuclear antibody (ANA) (12.8 +/- 1.8 vs. 8.3 +/- 4.5, P = 0.0372). The frequency of human leukocyte antigen (HLA) DR-8 in patients with HCV-related CLD seropositive for ACA was significantly higher than that in patients with CH-C seronegative for ANA (71 vs. 18%, P = 0.0108). These findings suggest that ACA is induced by chronic HCV infection in association with HLA DR-8, and that CH-C patients with ACA exhibit more severe hepatic fibrosis and inflammation than CH-C patients without ANA.
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