ArticleMolecular and cellular biochemistry2008
Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Distinct effects of obesity and diabetes on the action potential waveform and inward currents in rat ventricular myocytes.Clinical science (London, England : 1979) · 2025Article
- Protector Role of Cx30.2 in Pancreatic β-Cell against Glucotoxicity-Induced Apoptosis.Biology · 2024Article
- Dysglycemia and arrhythmias.World journal of diabetes · 2023Review
- Connexin 43 Phosphorylation: Implications in Multiple Diseases.Molecules (Basel, Switzerland) · 2023Review
- Gap Junctional Communication via Connexin43 between Purkinje Fibers and Working Myocytes Explains the Epicardial Activation Pattern in the Postnatal Mouse Left Ventricle.International journal of molecular sciences · 2021Article
- Protective effects of gallic acid on cardiac electrophysiology and arrhythmias during reperfusion in diabetes.Iranian journal of basic medical sciences · 2019Article
- Acute intramyocardial lipid accumulation in rats does not slow cardiac conduction per se.Physiological reports · 2019Article
- Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart.Frontiers in physiology · 2019Article
- Apelin Ameliorates High Glucose-Induced Downregulation of Connexin 43 via AMPK-Dependent Pathway in Neonatal Rat Cardiomyocytes.Aging and disease · 2018Article
- Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection.Cardiovascular diabetology · 2017Review
- Connexin channel and its role in diabetic retinopathy.Progress in retinal and eye research · 2017Review
- Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.Pharmacological reviews · 2017Review
- Upregulation of connexin 43 and apoptosis‑associated protein expression by high glucose in H9c2 cells was improved by resveratrol via the autophagy signaling pathway.Molecular medicine reports · 2017Article
- Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.Pharmacology & therapeutics · 2015Review
- Diet-induced pre-diabetes slows cardiac conductance and promotes arrhythmogenesis.Cardiovascular diabetology · 2015Article
- Alterations in connexin 43 during diabetic cardiomyopathy: competition of tyrosine nitration versus phosphorylation.Journal of diabetes · 2015Article
- Heart-protective effect of n-3 PUFA demonstrated in a rat model of diabetic cardiomyopathy.Molecular and cellular biochemistry · 2014Article
- Age-associated alterations of cardiac structure and function in the female F344xBN rat heart.Age (Dordrecht, Netherlands) · 2014Article
- Modeling and imaging cardiac sympathetic neurodegeneration in Parkinson's disease.American journal of nuclear medicine and molecular imaging · 2014Review
- Managing the complexity of communication: regulation of gap junctions by post-translational modification.Frontiers in pharmacology · 2013Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Abnormal QT prolongation with the associated arrhythmias is a significant predictor of mortality in diabetic patients. Gap junctional intercellular communication allows electrical coupling between heart muscle cells. The effects of streptozotocin (STZ)-induced diabetes mellitus on the expression and distribution of connexin 43 (Cx43) in ventricular muscle have been investigated. Cx43 mRNA expression was measured in ventricular muscle by quantitative PCR. The distribution of total Cx43, phosphorylated Cx43 (at serine 368) and non-phosphorylated Cx43 was measured in ventricular myocytes and ventricular muscle by immunocytochemistry and confocal microscopy. There was no significant difference in Cx43 mRNA between diabetic rat ventricle and controls. Total and phosphorylated Cx43 were significantly increased in ventricular myocytes and ventricular muscle and dephosphorylated Cx43 was not significantly altered in ventricular muscle from diabetic rat hearts compared to controls. Disturbances in gap junctional intercellular communication, which in turn may be attributed to alterations in balance between total, phosphorylated and dephosporylated Cx43, might partly underlie prolongation of QRS and QT intervals in diabetic heart.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.