ArticleSurgical endoscopy2009
Renal oxidative stress following CO2 pneumoperitoneum-like conditions.
Article in Surgical endoscopy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- General anesthesia type does not influence serum levels of neutrophil gelatinase-associated lipocalin during the perioperative period in video laparoscopic bariatric surgery.Clinics (Sao Paulo, Brazil) · 2014Trial
- Mediators of Regional Kidney Perfusion during Surgical Pneumo-Peritoneum Creation and the Risk of Acute Kidney Injury-A Review of Basic Physiology.Journal of clinical medicine · 2022Review
- First Report of Two Cases of Acute Gastric Ischemia after Robot-Assisted Radical Cystectomy.Case reports in urology · 2021Article
- Effects of pneumoperitoneum with carbon dioxide on renal and hepatic functions in rats.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2020Article
- The effects of prolonged COWideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2017Article
- Oxidants as important determinants of renal apoptosis during pneumoperitoneum: a study in an isolated perfused rat kidney model.Surgical endoscopy · 2012Article
- Carbon dioxide pneumoperitoneum induces anti-inflammatory response and hepatic oxidative stress in young rats with bacterial peritonitis.Pediatric surgery international · 2011Article
- Nitric oxide synthase inhibition aggravates the adverse renal effects of high but not low intraabdominal pressure.Surgical endoscopy · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysiologic renal changes associated with pneumoperitoneum (PNP) have been described and various underlying mechanisms have been suggested. We investigated the possibility that PNP-associated renal damage is pressure dependent, and that oxidative stress is thereby involved. MATERIALS AND
methodsSeventy Wistar rat kidneys (n=10 per group) were isolated. They were perfused with oxygenated, warm, Krebs-Henseleit solution containing 5% albumin within an isolated environment and subjected to various CO(2) pressures (0 [control], 3, 5, 8, 12, 15, and 18 mmHg) for 60 min. Half of each group was additionally perfused for 30 min at 0 mmHg pressure.
resultsRenal flow decreased proportionately to the applied pressure as did urine output: both decreased (P < 0.05) after 60 and 90 min when pressure >or=8 mmHg was applied. Oxygen extraction decreased (P<0.05) during PNP in all pressurized groups. Xanthine oxidase (XO) activity and reduced glutathione in the tissues increased (P<0.05) proportionately to pressures >or=8 mmHg. All parameters slightly reversed toward baseline values, upon the release of the intra-chamber pressure, except for the 18 mmHg group's values.
conclusionsCO(2)-PNP pressure induces kidney injury, possibly reversible immediately after pressure is annulled. Pressure is associated with oxidative stress, which interferes with cellular metabolism and function, possibly via an ischemic-reperfusion-like mechanism.
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