Evidence map›Paper›PMID 18629449›Full record

ReviewImmunologic research2009

Intrinsic and extrinsic control of effector T cell survival and memory T cell development.

Timothy W Hand, Susan M Kaech

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Perturbed T cell IL-7 receptor signaling in chronic Chagas disease.Journal of immunology (Baltimore, Md. : 1950) · 2015
    Trial
  2. Article
  3. Review
  4. Modifying enzyme replacement therapy - A perspective.Journal of cellular and molecular medicine · 2023
    Review
  5. Article
  6. Review
  7. Lack of Sprouty 1 and 2 enhances survival of effector CD8Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  8. Pathogens (Basel, Switzerland) · 2018
    Review
  9. Article
  10. Review
  11. Leishmania-encoded orthologs of macrophage migration inhibitory factor regulate host immunity to promote parasite persistence.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Transfer of CD8+ T cell memory using Bcl-2 as a marker.Journal of immunology (Baltimore, Md. : 1950) · 2013
    Article
  18. Self-boosting vaccines and their implications for herd immunity.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Timothy W HandDepartment of Immunobiology, Yale University School of Medicine, 300 Cedar St., TACS641B, P.O. Box 208011, New Haven, CT 06520, USA.
Susan M Kaech

Funding

Regulation of memory CD8 T cell developmentR01AI066232 · NIAID · YALE UNIVERSITY · PI Diana Clare Hargreaves · 2005 to 2026
$5.7M
NIAID NIH HHS R01 AI066232NIAID NIH HHS R01AI066232-0
6 · The paper itself

Abstract

Following infection or vaccination T cells expand exponentially and differentiate into effector T cells in order to control infection and coordinate the multiple effector arms of the immune system. Soon after this expansion, the majority of antigen-specific T cells die to reattain homeostasis and a small pool of memory T cells forms to provide long-term immunity to subsequent re-infection. Our understanding of how this process is controlled has improved considerably over the recent years, but many questions remain outstanding. This review focuses on the recent advancements in this area with an emphasis on how the contraction of activated T cells is coordinately regulated by a combination of factors extrinsic and intrinsic to the activated T cells.

Indexed as

AnimalsCell SurvivalCytokinesHumansImmune SystemImmunologic MemoryInfectionsLymphocyte ActivationLymphocyte SubsetsT-LymphocytesCytokines

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.