ArticleEnvironmental health perspectives2008
Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Breast cancer and persistent organic pollutants (excluding DDT): a systematic literature review.Environmental science and pollution research international · 2016Pooled it
- An Epidemiologic Review of Endocrine-disrupting Chemicals and Understudied Gynecologic Health Conditions Affecting Quality of Life.Current environmental health reports · 2026Review
- Methodologies and challenges in Arctic human health risk assessment: case studies and evaluation of current practices.International journal of circumpolar health · 2024Article
- Advancing understanding of human variability through toxicokinetic modeling, in vitro-in vivo extrapolation, and new approach methodologies.Human genomics · 2024Review
- Area-Based Geocoding: An Approach to Exposure Assessment Incorporating Positional Uncertainty.GeoHealth · 2021Article
- The role of epidemiology studies in human health risk assessment of polychlorinated biphenyls.Environmental research · 2021Review
- A case-control study of breast cancer risk and ambient exposure to pesticides.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- A breast cancer case-control study of polybrominated diphenyl ether (PBDE) serum levels among California women.Environment international · 2019Article
- Biomonitoring and Nonpersistent Chemicals-Understanding and Addressing Variability and Exposure Misclassification.Current environmental health reports · 2019Review
- Breast Cancer and Exposure to Organochlorines in the CECILE Study: Associations with Plasma Levels Measured at the Time of Diagnosis and Estimated during Adolescence.International journal of environmental research and public health · 2019Article
- Lactation history, serum concentrations of persistent organic pollutants, and maternal risk of diabetes.Environmental research · 2016Article
- Estimating Time-Varying PCB Exposures Using Person-Specific Predictions to Supplement Measured Values: A Comparison of Observed and Predicted Values in Two Cohorts of Norwegian Women.Environmental health perspectives · 2016Article
- Persistent organic pollutants and inflammatory markers in a cross-sectional study of elderly Swedish people: the PIVUS cohort.Environmental health perspectives · 2014Article
- Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease.International journal of molecular sciences · 2014Review
- Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women.Journal of exposure science & environmental epidemiology · 2012Article
- Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study.Environmental health : a global access science source · 2011Article
- Article
- Maternal exposure to polychlorinated biphenyls and the secondary sex ratio: an occupational cohort study.Environmental health : a global access science source · 2011Article
- Intrinsic human elimination half-lives of polychlorinated biphenyls derived from the temporal evolution of cross-sectional biomonitoring data from the United Kingdom.Environmental health perspectives · 2011Article
- A multi-individual pharmacokinetic model framework for interpreting time trends of persistent chemicals in human populations: application to a postban situation.Environmental health perspectives · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite experimental evidence, most epidemiologic studies to date have not supported an association between exposure to persistent organic pollutants (POP) and breast cancer incidence in humans. This may be attributable to difficulties in estimating blood/tissue POP concentration at critical time periods of carcinogenesis.
objectivesIn this work we aimed to develop a tool to estimate lifetime POP blood/tissue exposure and levels during any hypothesized time window of susceptibility in breast cancer development.
methodsWe developed a physiologically based pharmacokinetic (PBPK) model that can account for any given physiologic lifetime history. Using data on pregnancies, height, weight, and age, the model estimates the values of physiologic parameters (e.g., organ volume, composition, and blood flow) throughout a woman's entire life. We assessed the lifetime toxicokinetic profile (LTP) for various exposure scenarios and physiologic factors (i.e., breast-feeding, growth, pregnancy, lactation, and weight changes).
resultsSimulations for three POPs [hexachlorobenzene, polychlorinated biphenyl (PCB)-153, PCB-180] using different lifetime physiologic profiles showed that the same blood concentration at 55 years of age can be reached despite totally different LTP. Aside from exposure levels, lactation periods and weight profile history were shown to be the factors that had the greatest impact on the LTP.
conclusionsThis new lifetime PBPK model, which showed the limitations of using a single sample value obtained around the time of diagnosis for lifetime exposure assessment, will enable researchers conducting environmental epidemiology studies to reduce uncertainty linked to past POP exposure estimation and to consider exposure during time windows that are hypothesized to be mechanistically critical in carcinogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.