ArticleComparative and functional genomics2003
Mapping functional associations in the entire genome of Drosophila melanogaster using fusion analysis.
Article in Comparative and functional genomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- CGG toolkit: Software components for computational genomics.PLoS computational biology · 2023Article
- miR-375 Promotes Pancreatic DifferentiationStem cells international · 2021Article
- Protein functional links in Trypanosoma brucei, identified by gene fusion analysis.BMC evolutionary biology · 2011Article
- Computational prediction of protein-protein interactions.Molecular biotechnology · 2008Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that the detection of gene fusion events can contribute towards the elucidation of functional associations of proteins within entire genomes. Here we have analysed the entire genome of Drosophila melanogaster using fusion analysis and two additional constraints that improve the reliability of the predictions, viz. low sequence similarity and low degree of paralogy of the component proteins involved in a fusion event. Imposing these constraints, the total number of unique component pairs is reduced from 18 654 to a mere 220 cases, which are expected to represent some of the most reliably detected functionally associated proteins. Using additional information from sequence databases, we have been able to detect pairs of functionally associated proteins with important functions in cellular and developmental pathways, such as spermatogenesis and programmed cell death.
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Registered trials
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