ArticleComparative and functional genomics2005
Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe.
Article in Comparative and functional genomics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
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- Mitochondrial remodelling is essential for female germ cell differentiation and survival.PLoS genetics · 2023Article
- Cyclophilin A (CyPA) as a Novel Biomarker for Early Detection of Diabetic Nephropathy in an Animal Model.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- TOR Signaling inGenetics · 2019Review
- Genome-Wide Identification and Characterization of the Cyclophilin Gene Family in the Nematophagous FungusInternational journal of molecular sciences · 2019Article
- Genome-Wide Identification of Cyclophilin Gene Family in Cotton and Expression Analysis of the Fibre Development inInternational journal of molecular sciences · 2019Article
- Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis.The Journal of cell biology · 2017Article
- Protein aggregation activates erratic stress response in dietary restricted yeast cells.Scientific reports · 2016Article
- Calcium and reactive oxygen species in regulation of the mitochondrial permeability transition and of programmed cell death in yeast.Cell calcium · 2016Review
- Prolyl isomerases in gene transcription.Biochimica et biophysica acta · 2015Review
- The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.Physiological reviews · 2015Review
- Parvulin 17-catalyzed Tubulin Polymerization Is Regulated by Calmodulin in a Calcium-dependent Manner.The Journal of biological chemistry · 2015Article
- F-ATPase of Drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release.The Journal of biological chemistry · 2015Article
- The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection.Journal of molecular and cellular cardiology · 2015Review
- The ubiquitin proteasome system in Caenorhabditis elegans and its regulation.Redox biology · 2014Review
- Functional and pharmacological characteristics of permeability transition in isolated human heart mitochondria.PloS one · 2013Article
- Article
- Genetic control of necrosis - another type of programmed cell death.Current opinion in cell biology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins comprises three member families that are found throughout nature and are present in all the major compartments of the cell. Their numbers appear to be linked to the number of genes in their respective genomes, although we have found the human repertoire to be smaller than expected due to a reduced cyclophilin repertoire. We show here that whilst the members of the cyclophilin family (which are predominantly found in the nucleus and cytoplasm) and the parvulin family (which are predominantly nuclear) are largely conserved between different repertoires, the FKBPs (which are predominantly found in the cytoplasm and endoplasmic reticulum) are not. It therefore appears that the cyclophilins and parvulins have evolved to perform conserved functions, while the FKBPs have evolved to fill ever-changing niches within the constantly evolving organisms. Many orthologous subgroups within the different PPIase families appear to have evolved from a distinct common ancestor, whereas others, such as the mitochondrial cyclophilins, appear to have evolved independently of one another. We have also identified a novel parvulin within Drosophila melanogaster that is unique to the fruit fly, indicating a recent evolutionary emergence. Interestingly, the fission yeast repertoire, which contains no unique cyclophilins and parvulins, shares no PPIases solely with the budding yeast but it does share a majority with the higher eukaryotes in this study, unlike the budding yeast. It therefore appears that, in comparison with Schizosaccharomyces pombe, Saccharomyces cerevisiae is a poor representation of the higher eukaryotes for the study of PPIases.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.