ArticleComparative and functional genomics2004
Shotgun cloning of transposon insertions in the genome of Caenorhabditis elegans.
Article in Comparative and functional genomics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Forward and reverse mutagenesis in C. elegans.WormBook : the online review of C. elegans biology · 2014Review
- Engineering silkworms for resistance to baculovirus through multigene RNA interference.Genetics · 2013Article
- Article
- Low impact of germline transposition on the rate of mildly deleterious mutation in Caenorhabditis elegans.Genetics · 2006Article
- From genes to function: the C. elegans genetic toolbox.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a strategy to identify and map large numbers of transposon insertions in the genome of Caenorhabditis elegans. Our approach makes use of the mutator strain mut-7, which has germline-transposition activity of the Tc1/mariner family of transposons, a display protocol to detect new transposon insertions, and the availability of the genomic sequence of C. elegans. From a pilot insertional mutagenesis screen, we have obtained 351 new Tc1 transposons inserted in or near 219 predicted C. elegans genes. The strategy presented provides an approach to isolate insertions of natural transposable elements in many C. elegans genes and to create a large-scale collection of C. elegans mutants.
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Registered trials
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