ArticleComparative and functional genomics2003
Unravelling the ORFan Puzzle.
Article in Comparative and functional genomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- TRGdb: a universal resource for the exploration of taxonomically restricted genes in bacteria.Database : the journal of biological databases and curation · 2023Article
- Taxonomically Restricted Genes in Bacillus may Form Clusters of Homologs and Can be Traced to a Large Reservoir of Noncoding Sequences.Genome biology and evolution · 2023Article
- Yaravirus: A novel 80-nm virus infectingProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Disentangling the effects of selection and loss bias on gene dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Dark matter in archaeal genomes: a rich source of novel mobile elements, defense systems and secretory complexes.Extremophiles : life under extreme conditions · 2014Article
- Hypothetical proteins present during recovery phase of radiation resistant bacterium Deinococcus radiodurans are under purifying selection.Journal of molecular evolution · 2013Article
- Re-annotation of protein-coding genes in the genome of saccharomyces cerevisiae based on support vector machines.PloS one · 2013Article
- Article
- Novel genes exhibit distinct patterns of function acquisition and network integration.Genome biology · 2010Article
- Gene identification and protein classification in microbial metagenomic sequence data via incremental clustering.BMC bioinformatics · 2008Article
- Identification and investigation of ORFans in the viral world.BMC genomics · 2008Article
- Dynamic behavior of an intrinsically unstructured linker domain is conserved in the face of negligible amino acid sequence conservation.Journal of molecular evolution · 2007Article
- On the origin of microbial ORFans: quantifying the strength of the evidence for viral lateral transfer.BMC evolutionary biology · 2006Article
- The ORFanage: an ORFan database.Nucleic acids research · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ORFans are open reading frames (ORFs) with no detectable sequence similarity to any other sequence in the databases. Each newly sequenced genome contains a significant number of ORFans. Therefore, ORFans entail interesting evolutionary puzzles. However, little can be learned about them using bioinformatics tools, and their study seems to have been underemphasized. Here we present some of the questions that the existence of so many ORFans have raised and review some of the studies aimed at understanding ORFans, their functions and their origins. These works have demonstrated that ORFans are an untapped source of research, requiring further computational and experimental studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.