ArticlePloS one2008
Rheological characterization of the bundling transition in F-actin solutions induced by methylcellulose.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Morphological control of bundled actin networks subject to fixed-mass depletion.The Journal of chemical physics · 2024Article
- F-actin architecture determines the conversion of chemical energy into mechanical work.Nature communications · 2024Article
- F-actin architecture determines constraints on myosin thick filament motion.Nature communications · 2022Article
- Flagella-like beating of actin bundles driven by self-organized myosin waves.Nature physics · 2022Article
- A-to-I RNA editing of Filamin A regulates cellular adhesion, migration and mechanical properties.The FEBS journal · 2022Article
- Regulation of Actin Bundle Mechanics and Structure by Intracellular Environmental Factors.Frontiers in physics · 2021Article
- Article
- Filament Nucleation Tunes Mechanical Memory in Active Polymer Networks.Advanced functional materials · 2019Article
- Adaptive Response of Actin Bundles under Mechanical Stress.Biophysical journal · 2017Article
- Reconstitution of contractile actomyosin arrays.Methods in enzymology · 2014Article
- F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Actin filament attachments for sustained motility in vitro are maintained by filament bundling.PloS one · 2012Article
- Transformation of actoHMM assembly confined in cell-sized liposome.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Computational analysis of viscoelastic properties of crosslinked actin networks.PLoS computational biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many in vitro experiments Brownian motion hampers quantitative data analysis. Therefore, additives are widely used to increase the solvent viscosity. For this purpose, methylcellulose (MC) has been proven highly effective as already small concentrations can significantly slow down diffusive processes. Beside this advantage, it has already been reported that high MC concentrations can alter the microstructure of polymer solutions such as filamentous actin. However, it remains to be shown to what extent the mechanical properties of a composite actin/MC gel depend on the MC concentration. In particular, significant alterations might occur even if the microstructure seems unaffected. Indeed, we find that the viscoelastic response of entangled F-actin solutions depends sensitively on the amount of MC added. At concentrations higher than 0.2% (w/v) MC, actin filaments are reorganized into bundles which drastically changes the viscoelastic response. At small MC concentrations the impact of MC is more subtle: the two constituents, actin and MC, contribute in an additive way to the mechanical response of the composite material. As a consequence, the effect of methylcellulose on actin solutions has to be considered very carefully when MC is used in biochemical experiments.
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