ArticlePloS one2008
Major histocompatibility complex based resistance to a common bacterial pathogen of amphibians.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
- Metabolites of Xenorhabdus bacteria are potent candidates for mitigating amphibian chytridiomycosis.AMB Express · 2023Article
- Conserved Evolution of MHC Supertypes among Japanese Frogs Suggests Selection for Bd Resistance.Animals : an open access journal from MDPI · 2023Article
- Exposure to a fungal pathogen increases the critical thermal minimum of two frog species.Ecology and evolution · 2021Article
- Host-multiparasite interactions in amphibians: a review.Parasites & vectors · 2021Review
- Evolutionary principles guiding amphibian conservation.Evolutionary applications · 2020Review
- Article
- Major histocompatibility complex variation and the evolution of resistance to amphibian chytridiomycosis.Immunogenetics · 2017Review
- Characterization of MHC class IA in the endangered southern corroboree frog.Immunogenetics · 2017Article
- Major histocompatibility complex selection dynamics in pathogen-infected túngara frog (Physalaemus pustulosus) populations.Biology letters · 2016Article
- Research proceedings on amphibian model organisms.Dong wu xue yan jiu = Zoological research · 2016Review
- Positive selection drives the evolution of a major histocompatibility complex gene in an endangered Mexican salamander species complex.Immunogenetics · 2015Article
- Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation.Proceedings. Biological sciences · 2015Article
- Examining the role of components of Slc11a1 (Nramp1) in the susceptibility of New Zealand sea lions (Phocarctos hookeri) to disease.PloS one · 2015Article
- Social discrimination by quantitative assessment of immunogenetic similarity.Proceedings. Biological sciences · 2012Article
- Genetic diversity of MHC class I loci in six non-model frogs is shaped by positive selection and gene duplication.Heredity · 2012Article
- Ecological immunogenetics of life-history traits in a model amphibian.Biology letters · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given their well-developed systems of innate and adaptive immunity, global population declines of amphibians are particularly perplexing. To investigate the role of the major histocompatibility complex (MHC) in conferring pathogen resistance, we challenged Xenopus laevis tadpoles bearing different combinations of four MHC haplotypes (f, g, j, and r) with the bacterial pathogen Aeromonas hydrophila in two experiments. In the first, we exposed ff, fg, gg, gj, and jj tadpoles, obtained from breeding MHC homozygous parents, to one of three doses of A. hydrophila or heat-killed bacteria as a control. In the second, we exposed ff, fg, fr, gg, rg, and rr tadpoles, obtained from breeding MHC heterozygous parents and subsequently genotyped by PCR, to A. hydrophila, heat-killed bacteria or media alone as controls. We thereby determined whether the same patterns of MHC resistance emerged within as among families, independent of non-MHC heritable differences. Tadpoles with r or g MHC haplotypes were more likely to die than were those with f or j haplotypes. Growth rates varied among MHC types, independent of exposure dose. Heterozygous individuals with both susceptible and resistant haplotypes were intermediate to either homozygous genotype in both size and survival. The effect of the MHC on growth and survival was consistent between experiments and across families. MHC alleles differentially confer resistance to, or tolerance of, the bacterial pathogen, which affects tadpoles' growth and survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.